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AboutAboutConjugate TechnologyPneumococcal DiseaseDosing & AdministrationDosing & AdministrationDosing, Administration & StoragePrevious Pneumococcal VxClinical Trial ProgrammeClinical Evidence & SafetyClinical Trial ProgrammeSafety ProfilePrivate Vaccination Service Private Vaccination ServiceIdentifying Those at Increased Risk of Pneumococcal Pneumonia

The content of this site is based on the Prescribing Information for APEXXNAR®▼ (pneumococcal polysaccharide conjugate vaccine (20-valent, adsorbed)) for Great Britain. The Prescribing Information for Great Britain can be found here. Prescribing Information for Prevenar 13® (pneumococcal polysaccharide conjugate vaccine (13-valent, adsorbed)) can be found here.

Pneumococcal Disease

What is pneumonia?

Pneumonia is swelling (inflammation) of the tissue in one or both lungs, usually caused by a bacterial or viral infection.1,2 Pneumonia can affect anyone, although some groups are at higher risk.1,2

Symptoms of pneumonia

One of the most common symptoms of pneumonia is a cough, which can be dry or mucus producing (yellow, green, brownish or blood-stained).1,2

Other common symptoms include difficulty breathing, rapid heartbeat, fever, generally feeling unwell, sweating and shivering, loss of appetite, and chest pain.1,2

Mild cases can usually be treated at home, but may leave sufferers with a persistent cough for up to 6 weeks and lasting fatigue.3 Severe cases may require hospitalisation due to a higher risk of developing serious complications.1

Causes of pneumonia

Pneumonia is usually caused by bacteria or viruses. It can also be caused by fungal infections or aspiration of food.1,2


Streptococcus pneumoniae is the most common bacterial cause of pneumonia.2 

  • In adults aged 50 years and older, Streptococcus pneumoniae infections are responsible for approximately 36% of all hospitalised cases of community-acquired pneumonia (CAP).7

A pneumonia infection caused by Streptococcus pneumoniae is known as pneumococcal pneumonia, which is a form of pneumoccocal disease.2,6,8


† 36% of patients = 861 patients hospitalised with pneumococcal CAP out of 2412 patients hospitalised with all cause CAP.

Example

About APEXXNAR

Learn about Conjugate Vaccine Technology

 

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Clinical Trial Programme

The safety profile and immunogenicity of APEXXNAR was evaluated in 4,552 adults in 6 clinical trials9

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Key Information on APEXXNAR

Key information about dosing, administration and storage for APEXXNAR9
 

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References

NHSinform. Pneumonia. Available at https://www.nhsinform.scot/illnesses-and-conditions/lungs-and-airways/pneumonia. Last accessed February 2024.Asthma and Lung UK. Pneumonia. Available at: https://www.blf.org.uk/support-for-you/pneumonia/what-is-pneumonia. Last accessed February 2024.Asthma and Lung. Recovering from Pneumonia. Available at: https://www.asthmaandlung.org.uk/conditions/pneumonia/recovery. Last accessed February 2024.Office of National Statistics: Deaths due to coronavirus (COVID-19) compared with deaths from influenza and pneumonia, England and Wales: deaths occurring between 1 January and 31 August 2020. Available at:      https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsduetocoronaviruscovid19comparedwithdeathsfrominfluenzaandpneumoniaenglandandwales/deathsoccurringbetween1januaryand31august2020. Last accessed February 2024.NHS Digital. Hospital Episodes Statistics for England. NHS Digital. Hospital Admitted Patient Care Activity, 2022-23. Available at: https://digital.nhs.uk/data-and-information/publications/statistical/hospital-admitted-patient-care-activity/2022-23. Last accessed February 2024.UK Health Security Agency. The Green Book [published 2013; updated 2023]. Chapter 25: Pneumococcal. Available at https://www.gov.uk/government/publications/pneumococcal-the-green-book-chapter-25. Last accessed February 2024.Pick H, et al. Pneumococcal serotype trends, surveillance and risk factors in UK adult pneumonia, 2013-18.Thorax. 2020;75(1):38-49NHSinform. Pneumococcal infections. Available at: https://www.nhsinform.scot/illnesses-and-conditions/infections-and-poisoning/pneumococcal-infections/. Last accessed February 2024.APEXXNAR (Pneumococcal polysaccharide conjugate vaccine[20-valent,adsorbed]) Summary of Product Characteristics GB. 
PP-PNR-GBR-0152. March 2024

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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