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HomeEfficacyATGAM® efficacyEfficacy homeTrial: ATGAM® versus rabbit ATGTrial: ATGAM® ± sirolimusTrial: ATGAM® other pivotal studiesSafetyDosing & administrationSupport & resourcesMaterialVideo

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Efficacy
ATGAM®▼ (horse anti-human T-lymphocyte immunoglobulin) other pivotal studies

The use of ATGAM® has a well-documented profile established from several clinical studies and reports1-3

In three studies, ATGAM® was administered over 8 or 10 days to a total of 115 patients with moderate-to-severe aplastic anaemia1-3

Dosing regimens consisted of 20 mg/kg for 8 days or 16 mg/kg for 10 daysa

Overall haematological responseb rates for ATGAM®-treated patients were 39–52% at either 3 or 6 months1-3

Survival rates ranged between 50–83% over 1–2 years1-3

aATGAM® was administered in various combinations across the studies, including placebo, bone marrow infusion, oxymetholone or androgen.1
bHematological response is defined differently in these different pivotal studies.References:ATGAM® Summary of Product Characteristics. Pfizer Inc.Champlin R, et al. N Engl J Med. 1983;308:113-1187.Champlin RE, et al. Blood. 1985;66:184-188 

Prescribing Information
Click here for Prescribing Information for ATGAM (horse anti-human T-lymphocyte immunoglobulin)ATGAM® efficacyLearn about the safety profile of ATGAM®  Find out more LoadingLearn about ATGAM® dosing & administration Find out more LoadingMore information is available in support & resources Explore resources Loading
PP-ATG-GBR-0025. February 2023

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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