Click here for BeneFIX® (nonacog alfa) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.
Reliable efficacy when you and your patients need it most1–3
Prophylaxis
Prophylactic treatment in PTPs
of responses were rated as excellent or effective (n=47)1,*
Prophylactic treatment in PUPs
of responses were rated as excellent† (n=42), indicating that spontaneous musculoskeletal bleeding was prevented2
Paediatric patients
of patients under 6 years old experienced no spontaneous bleeding episodes whilst on prophylaxis (n=22)4
The response to secondary prophylaxis was assessed once every 3 months by the investigator using a 3-point scale: excellent (no spontaneous bleeding of any kind, no change in dosing regimen necessary); effective (no spontaneous musculoskeletal bleeding, no change in dosing regimen necessary); or inadequate (inadequate prevention of bleeding requiring a change in dosing regimen).1
†Rated by the investigator at 3-month intervals on a 3-point scale: excellent (prophylaxis treatment completely prevented spontaneous musculoskeletal bleeding, no change in dosing regimen necessary); effective (adequately prevented spontaneous musculoskeletal bleeding episodes as demonstrated by a lower than expected incidence of spontaneous musculoskeletal bleeding episodes); or inadequate (inadequate prevention of bleeding requiring a change in dosing regimen).2
On-demand treatment
On-demand treatment in PTPs
of 1,796 bleeding episodes were resolved with only 1 infusion (n=55)1
On-demand treatment in PUPs
of 997 bleeding episodes were resolved with only 1 infusion (n=54)2
Surgery
of responses were rated excellent or good‡ (n=28)3,§
‡ Haemostasis was rated as excellent or good in 34 out of 35 of the operative procedures. Response ratings are defined as follows: excellent if the response was as satisfactory, with as much and as rapid an improvement as the best responses with other factor IX products for similar bleeds or procedures; good if the response was as satisfactory, with as much and as rapid an improvement as most responses with other factor IX products for similar bleeds or procedures; moderate if the response was less than satisfactory and not as good as most responses seen with other factor IX products when used for similar bleeding episodes or similar procedures; or no response if no improvement at all was observed.3
§ 29% (8/28) of patients (9 operative procedures) received postoperative BeneFIX by continuous infusion.3 BeneFIX is not licensed for use by continuous infusion – please refer to the BeneFIX Summary of Product Characteristics for further information.5
Explore more
Find out about the safety profile of BeneFIX
Find out about BeneFIX dosing
- Roth DA et al. Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates. Blood 2001;98(13):3600–3606.
- Shapiro AD et al. The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. Blood 2005;105(2):518–525.
- Ragni MV et al. Use of recombinant factor IX in subjects with haemophilia B undergoing surgery. Haemophilia 2002;8(2):91–97.
- Monahan PE et al. Safety and efficacy of investigator-prescribed BeneFIX prophylaxis in children less than 6 years of age with severe haemophilia B. Haemophilia 2010;16(3):460–468.
- BeneFIX (nonacog alfa) Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/6157/smpc.
Contact Pfizer
Speak to a member of the Pfizer haemophilia team.
Find out about administration & reconstitution of BeneFIX
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PP-PFE-GBR-2688. December 2020
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