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BeneFIX (nonacog alfa) Prescribing Information for Great Britain click here. BeneFIX (nonacog alfa) Prescribing Information for Northern Ireland click here.
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Adverse event reporting can be found at the bottom of this page.    

​​​​​​​BeneFIX® (nonacog alfa) is recombinant coagulation factor IX indicated for the treatment and prophylaxis of bleeding in patients with haemophilia B (congenital factor IX deficiency). BeneFIX® can be used for all age groups.1  

BeneFIX® monitoring  

During the course of treatment, appropriate determination of factor IX levels is advised to guide the dose to be administered and the frequency of repeated infusions.1

Dose based on bodyweight may require adjustment in underweight or overweight patients. Individual patients may vary in their response to factor IX, demonstrating different half-lives and recoveries.1  

In the case of major surgical interventions in particular, precise monitoring of the substitution therapy by means of coagulation analysis (plasma factor IX activity) is indispensable.1  

When using an in vitro thromboplastin time (aPTT)-based one stage clotting assay for determining factor IX activity in patients' blood samples, plasma factor IX activity results can be significantly affected by both the type of aPTT reagent and the reference standard used in the assay. This is of importance particularly when changing the laboratory and/or reagents used in the assay.1  

Monitoring

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Administration and storage

The R2 device is used for reconstitution of BeneFIX® by injection. 

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Recommended dosing schedules1

No two days are the same. No two patients are the same. BeneFIX® offers frequent, flexible dosing so your patients are covered for everyday life.1–3 ​​​​​​​​​​​​​​

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BeneFIX® in the real-world setting  

rFIX products like BeneFIX® are effective at preventing bleeds in everyday settings. 

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** This is an optional area where footnotes can live.

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Contact a member of the Pfizer haemophilia team.  

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** This is an optional area where footnotes can live.


References
  1. BeneFIX® Summary of Product Characteristics. For Great Britain, available here. For Northern Ireland, available here.
  2. Shapiro AD et al. Blood 2005;105(2):518–525.  
  3. Berntorp E, Andersson N. Semin Thromb Hemost. 2016;42:518–525.  
  4. Chhabra A et al. Blood Coagul Fibrinolysis 2020;31(3):186–192.       
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
​​​​​​​Adverse events should also be reported to Pfizer Medical Information on 01304 616161.

PP-BEN-GBR-0491. September 2021.

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PP-PFE-GBR-3863. November 2021

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