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EfficacyEfficacyEfficacyKey HighlightsHospitalisation DataSafetySafetySafetyAdverse Event Management: VOD/SOSKey PrecautionsDosingDosingDosingAdministrationSupport and ResourcesSupport and ResourcesVideosMaterialsPatient SupportKing's College Hospital: VOD Models of CareDr Castleton: Frontline approaches to B-cell ALL Dr Castleton: Management of relapsed disease in adult ALLDr Nicholson: Treatment landscape in R/R B-cell ALLDr Nicholson: Q&AMRD PubExplainer videoINO-VATE PubExplainer video

The content of this website has been produced in line with the BESPONSA® (inotuzumab ozogamicin) Summary of Product Characteristics for Great Britain and is intended for Healthcare Professionals based in Great Britain. BESPONSA Prescribing Information for Great Britain click here. BESPONSA Prescribing Information for Northern Ireland click here. Adverse event reporting information can be found at the bottom of the page.

Besponsa® (inotuzumab ozogamicin)

BESPONSA is indicated as monotherapy for the treatment of adults with relapsed or refractory CD22-positive B cell precursor acute lymphoblastic leukaemia (ALL). Adult patients with Philadelphia chromosome positive (Ph+) relapsed or refractory B cell precursor ALL should have failed treatment with at least 1 tyrosine kinase inhibitor (TKI).1

BESPONSA is recommended by NICE as an option for treating relapsed or refractory CD22-postive B-cell precursor ALL in adults2. People with relapsed or refractory Philadelphia chromosome positive disease should have had at least 1 tyrosine kinase inhibitor2.

Log in/Register to access further BESPONSA information

Log in/Register to PfizerPro to access further information on BESPONSA including:

  • Efficacy & Safety Data including the INO-VATE Trial analysis3,4
  • Support & Resources; download assets for support within your practice and video content developed in partnership with industry key opinion leaders
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Resources to support you

Dr Anna Castleton: Updates in Acute Lymphoblastic Leukaemia

Across a series of short videos, watch Dr Anna Castleton provide an update on the current upfront approaches in Adult B-cell and Ph-Positive ALL and the management of relapse disease including the role of CAR-T therapy. 

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Dr Emma Nicholson: The treatment landscape in R/R B-cell ALL

Dr. Emma Nicholson discusses the evolving treatment landscape in R/R B-cell ALL in the context of a  60-year-old patient case study as well as providing a particular focus on the targeted therapies available for use in R/R ALL.

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Addressing an area of service development
Hear Michelle Kenyon and Dr Daniele Avenoso from King's College Hospital  discuss a new model of care which is a standardised and systematic approach to the screening, assessment and diagnosis of veno-occlusive disease (VOD).
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BESPONSA Materials

Download materials to support you with the use of BESPONSA and managing patients with ALL.

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BESPONSA Videos

Watch on-demand videos from KOLs exploring the ALL landscape and patient case studies. 

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ALL , acute lymphoblastic leukaemia; B-cell ALL, B-cell acute lymphoblastic leukaemia; CAR, chimeric antigen receptor; KOL, key opinion leader; Ph-positive ALL, philadelphia chromosome-positive acute lymphoblastic leukaemia; R/R, relapsed/refractory.

References

BESPONSA Summary of Product Characteristics for Great Britain click here. BESPONSA Summary of Product Characteristics for Northern Ireland click here.NICE Technology Appraisal Guidance (TA541). Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia. Available at: https://www.nice.org.uk/guidance/TA541 Published: 19 September 2018. [accessed February 2024].Kantarjian HM, et al. New Engl J Med. 2016;375:740-53.Kantarjian HM, et al. New Engl J Med. 2016;375:740-53.  Supplementary appendix
PP-INO-GBR-0828. March 2024

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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