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Click here for Besponsa® (inotuzumab ozogamicin) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.


Enable outpatient treatment with convenient 1 hour infusion1​​​​​​​

BESPONSA is dosed three times per 3- to 4-week cycle, over 1 hour on Days 1, 8, and 15, for 1–6 cycles1

Cycle numbers

  • If the patient is proceeding to HSCT, 2 cycles are recommended. A 3rd cycle can be considered if CR/CRi and MRD negativity is not achieved
  • If NOT proceeding to HSCT, a maximum of 6 cycles can be given but BESPONSA should be discontinued after 3 cycles if CR/CRi is not achieved.​​​​​​​

BESPONSA Dosing Regimen

BESPONSA is administered as a 1-hour infusion in 21- or 28-day cycles

*± 2 days (maintain a minimum of 6 days between doses).
†The first cycle of BESPONSA is 21 days, while Cycles 2–6 are each 28 days. Cycle 1 may be extended to 28 days for patients achieving CR/CRi and/or if recovery from toxicity is needed.
‡CR defined as < 5% blasts in the bone marrow and the absence of peripheral blood leukaemic blasts, full recovery of peripheral blood counts (platelets ≥ 100 × 109/L and ANC ≥ 1 × 109/L), and resolution of any EMD; CRi defined as < 5% blasts in the bone marrow and the absence of peripheral blood leukaemic blasts, incomplete recovery of peripheral blood counts (platelets < 100 × 109/L and/or ANC < 1 × 109/L) and resolution of any EMD.
§7-day treatment-free interval starting on day 21.

ANC, absolute neutrophil count; CR, complete remission; CRi, complete remission with incomplete haematological recovery of peripheral blood counts; EMD, extramedullary disease; HSCT, haematopoietic stem cell transplantation; MRD, minimal residual disease.

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Fast Facts

Download the Fast Facts PDF document to aid your understanding of BESPONSA. SmPC should be consulted for full guidance.

Download here

Pharmacy Guide

Download the guide for Pharmacists for information on dosing, drug interactions, reconstitution, administration, shelf life etc. SmPC should be consulted for full guidance.

Download here

▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.
  1. Pfizer Limited. BESPONSA® Summary of Product Characteristics. Available at: [accessed March 2021].
PP-INO-GBR-0392. March 2021

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PP-PFE-GBR-2688. December 2020