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The content of this website has been produced in line with the BOSULIF® (bosutinib) Summary of Product Characteristics for Great Britain and Northern Ireland. For BOSULIF® (bosutinib) Prescribing Information Click here. Adverse event reporting information can be found at the bottom of the page.

Bosulif Dosing Guide

For information on dosing and dose adjustments, view Dosing Guide

 Download here Loading Recommended starting dose in FIRST-LINE1

400mg BOSULIF for adult patients with newly-diagnosed chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukaemia (Ph+ CML)

 Recommended starting dose in SECOND-LINE AND BEYOND1 500mg BOSULIF for adult patients with CP, accelerated phase (AP), and blast phase (BP) Ph+ CML previously treated with one or more tyrosine kinase inhibitor(s) and for whom imatinib, nilotinib and dasatinib are not considered appropriate treatment options

DOSE ADJUSTMENT1

100mg BOSULIF for dose escalation and reduction in increments between 300mg and 600mg (known as range of efficacy), depending on patient response and tolerability. Please refer to Summary of Product Characteristics for full guidance on when to escalate or reduce BOSULIF dosing by 100mg increments.

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Colour and size of tablets shown are not representative of the actual tablets and are for illustrative purposes only. 100 mg tablets width : 5.6 mm, length : 10.7 mm : 400 mg tablets width : 8.8 mm, length : 16.9 mm : 500 mg tablets width : 9.5 mm, length 18.3 mm. 1

References:

BOSULIF Summary of Product Characteristics for Great Britain click here. BOSULIF Summary of Product Characteristics for Northern Ireland click here.  
PP-BOS-GBR-1614. June 2022
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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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