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*MMR (≤0.1% BCR-ABL1 transcripts on the international scale in patients with ≥3000 ABL transcripts assessed at month 3).
†Adjusted for Sokal risk group and region at time of random assignment.
‡MR4, ≤0.01% BCR-ABL1 transcripts on the international scale.
§MR4.5, ≤0.0032% BCR-ABL1 transcripts on the international scale.
ABL, Abelson; BCR, breakpoint cluster region; CI, confidence interval; CML, chronic myelogenous leukaemia; mITT, modified intention-to-treat; MMR, major molecular response; MR, molecular response; OR, odds ratio.
*Patients who received one or more doses of study drug
AE, adverse event; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CML, chronic myelogenous leukaemia; SmPC, Summary of Product Characteristics.
Adapted from: Brümmendorf TH, et al. Leukemia 2022. doi: 10.1038/s41375-022-01589-y Supplementary materials.
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PP-PFE-GBR-3863. November 2021