The content of this website has been produced in line with the BOSULIF®▼ (bosutinib) Summary of Product Characteristics for Great Britain and is intended for Healthcare Professionals based in Great Britain. BOSULIF▼ Prescribing Information for Great Britain and for Northern Ireland, and adverse event reporting information can be found at the bottom of the page.
BOSULIF has been tested in a large number of patients and demonstrates efficacy in a wide range of patient types
Patient cohorts (N = 574* including patients receiving ≥ 1 dose of BOSULIF)
Primary cohort: imatinib resistant
Sub-group: Imatinib intolerant
IMI-R/I + dasatinib
IMI-R/I + dasatinib intolerant (n=50)
IMI-R/I + nilotinib
IMI-R/I + nilotinib
Sub-group: Accelerated phase
Sub-group: Blast phase (n=64)
*Includes 24 patients who were Ph+ ALL.3
†Third- and fourth-line subgroups comprise patients with CP CML that were imatinib resistant or imatinib intolerant and ≥ 1 of the following: Dasatinib resistant or dasatinib intolerant, nilotinib resistant, nilotinib intolerant or resistant/intolerant to dasatinib and nilotinib.
Primary endpoint‡: 33% (95% CI, 27–40%) MCyR at 24 weeks in imatinib-resistant patients (n=200)1,5
Results show that the best cumulative response is either attained or maintained.
*Minimum follow-up period was 5 years (CP 2nd-line) or 4 years (CP 3rd-/4th-line and AP/BP).
Criteria used: Resistant mutation; medical history or evidence of prior TKI intolerance.
†Received ≥ 1 BOSULIF dose and had a valid baseline assessment for the corresponding endpoint.
‡In patients with CP imatinib-resistant CML and no previous TKI exposure other than imatinib.
Watch Prof. Richard Clark discuss the holistic approach to treatment decisions for patient with CML
Learn more on TKIs in CML
Compare 2013 guidelines to those published in 2020
Download the pdf
For Great Britain
Bosulif (bosutinib) Prescribing Information - 100mg Tablets
Bosulif (bosutinib) Prescribing Information - 400mg Tablets
Bosulif (bosutinib) Prescribing Information - 500mg Tablets
For Northern Ireland
Bosulif (bosutinib) Prescribing Information
These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
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PP-PFE-GBR-2688. December 2020