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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Click here for Bosulif® (bosutinib monohydrate) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Safety data

A well defined and manageable safety profile1

y-axis: AE, x-axis: patients, %

*Patients who received one or more doses of study drug for either newly diagnosed CP CML or were resistant or intolerant to prior therapy with CP, AP, BP CML or Ph+ ALL. 
The data shown includes real-world data in addition to safety data from the BFORE trial and Study 200.

1% of the overall patient safety population discontinued due to diarrhoea1

No new cardiac or vascular safety signals at 24 months in newly diagnosed patients2​​​​​​​

Safety events for study population exposed to bosutinib/imatinib

*Patients who received one or more doses of study drug.

Further information

Please refer to the BOSULIF SmPC for full details of adverse events

If you still require further information, please contact Medical Information

BOSULIF SmPC Medical Information

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Perspectives in Managing CML

Hear views from the MDT: Rebecca Hallam (nurse) and Andrea Preston (pharmacy) on how to support patients through their treatment

Learn more

TKI adherence: a series of 3 videos

Hear from Dr Lina Eliasson on managing adherance with TKIs and fatigue

Watch the videos

AE, adverse event; ALL, acute lymphoblastic leukaemia; ALT, alanine aminotransferase; AP, accelerated phase; AST, aspartate aminotransferase; BP, blast phase; CML, chronic myeloid leukaemia; CP, chronic phase; Ph+, Philadelphia chromosome-positive; SmPC, Summary of Product Characteristics.
 This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.
References:
  1. ​​​​​​​BOSULIF (bosutinib) Summary of Product Characteristics.
  2. Cortes et al. Presented at American Society of Clinical Oncology Annual Meeting, 2018; Oral presentation 7002
PP-BOS-GBR-1001. March 2021
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