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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Click here for Bosulif® (bosutinib monohydrate) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

TKIs in CML and the holistic approach to treatment decisions video

Speaker: Professor Richard Clark

Duration: 03:56

​​​​​​​In this video, Richard discusses:

  • ​​​​​​​Chromosomal abnormalities
  • Prognostic markers
  • Longer term clinical data for bosutinib
  • His approach to changing treatments either due to efficacy or side effects

Richard Clark is Professor of Haematology at the University of Liverpool, UK. He studied medicine at Cambridge and Westminster Medical School, London, and, after his junior posts, co-established myeloid leukaemia research at Cardiff with Professor Allan Jacobs, as a research fellow and later Senior Lecturer. He moved to Liverpool in 1990 as Senior Lecturer and Consultant Haematologist and Director of the Regional Bone Marrow Transplant (BMT) programme at Royal Liverpool University Hospital. 
​​​​​​​Professor Clark’s research interests over the past 30 years have been in myeloid leukaemias, especially chronic myeloid leukaemia (CML). He is the chief or principal investigator for numerous trials in both acute leukaemia and myeloid malignancies and most recently the lead and chief investigator of one of the largest UK-wide study of discontinuation of TKIs in CML. 

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Review ELN Guidelines

Compare 2013 guidelines to those published in 2020

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New challenges: long-term TKI therapy

Hear Dr. Alex Lyon’s views on long-term TKI treatment in an ageing patient population video​​​​​​​​​​​​

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 This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.
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