Champix® (varenicline tartrate) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.
No psychiatric history
With a psychiatric history
Patients with COPD
Patients with CVD
The most common psychiatric disorders in the EAGLES study psychiatric cohort were: primary affective disorders, anxiety disorders, psychotic disorders and personality disorders.1†
† Patients had to be considered clinically stable for inclusion (i.e. no exacerbations ≤6 months; on stable treatment ≥3 months, with no treatment change anticipated during the study).1†
*CHAMPIX versus placebo, weeks 9-12, 0R=4.00 (95% Cl 3.20-5.00), p<0.0001, weeks 9-24 0R=2.99 (95% Cl 2.33-3.83), p<0.0001; versus NRT patch, weeks 9-12 OR=1.7 4 (95% Cl 1.43-2.10), p<0.0001, weeks 9-24 OR=1.52 (95% Cl 1.23-1.89), p=0.0001; versus bupropion, weeks 9-12 OR=1.77
(95% Cl 1.46-2.14), p<0.0001, weeks 9-24, OR=1.49 (95% Cl 1.20-1.85), p=0.0003. Based on the all-randomised patient population. †The primary efficacy endpoint was the CO-confirmed CAR from weeks 9-12. ‡The main secondary endpoint was the CO-confirmed CAR from weeks 9-24. The other secondary endpoint was the 7-day point prevalence of abstinence at each assessment visit, which yielded results consistent with the continuous abstinence rates.
Please refer to the Warnings and Precautions.
EAGLES: adverse events:1
Across the cohorts, the most frequent adverse events by treatment group were as follows:
Read about how Champix compares to nicotine replacement therapies.
Download support material for patients prescribed Champix.
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PP-PFE-GBR-2688. December 2020