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Champix® (varenicline tartrate) Prescribing Information.  Adverse event reporting information can be found at the bottom of the page.

Champix in Different Patient Types

Champix has been studied in a range of different patient types:1-4

No psychiatric history

With a psychiatric history

Patients with COPD

Patients with CVD

Champix is efficacious in patients with mild to moderate Chronic Obstructive Pulmonary Disease (COPD).2

For smokers with mild-to-moderate COPD, CHAMPIX offers:

  • Greater odds of quitting smoking at 12 weeks vs. placebo2 (47.0% vs. 13.9%; OR=6.11; 95% Cl: 4.18-8.93; p<0.0001) 
  • Greater odds of remaining abstinent at 1 year vs. placebo2 (19.2% vs. 7.2%; OR=3.14; 95% Cl: 1.93-5.11; p<0.0001) 
  • A favourable tolerability profile with discontinuation rates similar to placebo (CHAMPIX 5.2% vs. placebo 5.6%)2

Champix and COPD adverse events

The most frequently reported adverse events (AEs) in the CHAMPIX vs. placebo groups (15% in either group):2

  • Nausea (27% vs. 8.0%) 
  • Abnormal dreams (10.9% vs 2.8%)
  • Upper-respiratory tract infection (9.7% vs 8.4%) 
  • Insomnia (9.7% vs. 6.0%) 
  • Headache (8.1 % vs. 8.0%) 
  • Flatulence (7.3% vs. 5.2%) 
  • Vomiting (6.5% vs. 2.4%) 

Please refer to the summary of product characteristics for further information on the safety profile of Champix

  1. Anthenelli RM. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. Lancet 2016;387:2507-2520.
  2. Tashkin DP, et al. Effects of varenicline on smoking cessation in patients with mild-moderate COPD. Chest. 2011;139(3):591-599.
  3. Rigotti NA et al. Efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease. A randomised trial. Circulation. 2010;121: 221-2 29.
  4. Mills EJ, et al. Comparisons of high dose and combination nicotine replacement therapy, varenicline and bupropion for smoking cessation: A systematic review and multiple treatment meta-analysis. Ann Med. 2012;44:588-597.
  5.  CHAMPIX Summary of Product Characteristics
PP-CHM-GBR-3358. June 2021

Champix efficacy vs NRT

Read about how Champix compares to nicotine replacement therapies.

Champix efficacy data

Support material for Champix patients

Download support material for patients prescribed Champix.


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PP-PFE-GBR-2688. December 2020