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AboutAboutHow Cibinqo worksIntroducing CibinqoMOA OverviewPatient ProfilesPatient Profiles OverviewPatient Profile 1Patient Profile 2Patient Profile 3Patient Profile 4EfficacyEfficacyClinical EfficacyStudy OverviewJADE COMPAREJADE MONOJADE REGIMENJADE TEENJADE EXTENDSafety
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Information on how to access Cibinqo® (abrocitinib) prescribing information and adverse event reporting can be found at the bottom of the page.

Mode of actionCibinqo (abrocitinib) is a small molecule that works inside the cell to inhibit JAK11 ​​​​

Cibinqo is a Janus kinase (JAK)1 inhibitor.1
​​​​​​​ JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cell surface to influence haematopoiesis and immune cell function.1
​​​​​​​ JAKs phosphorylate and activate STATs, which in turn modulate activity in the cell. Inhibition of JAK1 interrupts signalling pathways by preventing the phosphorylation and activation of STATs.1
Key cytokines signal through JAK11-10By inhibiting JAK1, production of key signalling cytokines that drive AD inflammation, itch and skin barrier disruption are decreased.1–5



IL-4 and IL-13 are important mediators of type 2 inflammation and are major drivers of atopic inflammation.

image image​​​​​​​


IL-31 is a type 2 inflammatory cytokine that plays a role in mediating itch and atopic inflammation.

TSLP has been shown to promote atopic inflammation and is believed to play a role in itch.

image​​​​​​​ image


IL-22 helps induce epidermal hyperplasia and skin barrier disruption in AD.

In addition to the roles of the cytokines described here, these, and other cytokines are believed to play multiple roles in AD pathophysiology.8,9

The role of the JAK/STAT pathway

The JAK/STAT pathway is believed to be an important mediator of the pathophysiology of atopic dermatitis.11 JAKs are a family of intracellular cytoplasmic protein tyrosine kinases that are associated with cytokine and growth factor receptor subunits.2,3,10–12

Upon binding of proinflammatory cytokines, cytokine receptors dimerise, bringing JAK pairs into close proximity​​​​​​​.2,3,10–12

The paired JAKs then phosphorylate and activate each other​​​​​​​.2,3,10–12

JAK-mediated phosphorylation of the cytokine receptor creates a binding site for STATs.2,3,10–12

STATs are recruited and phosphorylated by activated JAKs.2,3,10–12

Activated STAT dimers move into the nucleus resulting in increased transcription of proinflammatory cytokine genes.2,3,10–12

Explore moreEfficacy

Cibinqo has been studied across six Phase III trials as monotherapy or in combination with medicated topical therapies.1–7

Explore the JADE clinical trialsLoadingReferences: 1. Cibinqo (abrocitinib) Summary of Product Characteristics. 2. Bieber T, et al. N Eng J Med 2021;384:1101–1112. 3. Simpson E, et al. Lancet 2020;395:P255–266. 4. Silverberg J, et alJAMA Dermatol 2021;156(8):863–873. 5. Blauvelt A, et al. JAAD 2021; 6. Eichenfield L, et al. JAMA Dermatol 2021;doi: 10.1001/jamadermatol.2021.2830. 7. NCT03422822. Available from:

3,128 patients were treated with Cibinqo in clinical studies in AD representing 2,089 patient-years of exposure.1

View safety guidanceLoadingReferences: 1. Cibinqo (abrocitinib) Summary of Product Characteristics.
Cibinqo (abrocitinib) Summary of Product Characteristics.Hammarén HM, et al. Cytokine 2019;118:48–63.Paller AS, et al. J Allergy Clin Immunol. 2017;140(3):633–643.Guttman-Yassky E, et al. Expert Opin Biol Ther 2013;13(4):549–561.Mollanazar NK, et al. Clin Rev Allergy Immunol 2016;51(3):263–292.Čepelak I, et al. Biochem Med (Zagreb) 2019;29(2):020501.Weidinger S, Novak N. Lancet 2016;387(10023):1109–1122.Howell MD, et al. Front Immunol 2019;10:2342.Langan SM, et al. Lancet 2020;396(10247):345–360.Morris R, et al. Protein Sci 2018;27(12):1984–2009.Clark JD, et al. J Med Chem 2014; 57(12):5023–5038.Damsky W, King BA. J Am Acad Dermatol 2017;76(4):736–744.
PP-CIB-GBR-0054. October 2021

Cibinqo Risk Minimisation Programme (RMP) materials, including a Patient Card and Prescriber Brochure, are available from Patients treated with Cibinqo should be given the Patient Card.

Mode of action

Adverse events should be reported. Reporting forms and information can be found at or search 

for MHRA Yellow Card in Google Play or Apple App Store

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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