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AboutAboutHow Cibinqo worksIntroducing CibinqoMOA OverviewPatient ProfilesPatient Profiles OverviewPatient Profile 1Patient Profile 2Patient Profile 3Patient Profile 4EfficacyEfficacyClinical EfficacyStudy OverviewJADE COMPAREJADE MONOJADE REGIMENJADE TEENJADE EXTENDSafety
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Information on how to access Cibinqo® (abrocitinib) prescribing information and adverse event reporting can be found at the bottom of the page.

PATIENT PROFILE 1Unemployed male with increasingly uncontrolled itching leading to sleep deprivation, weight gain and low self-esteem​​​​​​​Who is the patient?

This patient profile is fictional and has been produced for the purposes of medical education. Any actual or potential likeness to real individuals is unintentional.​​​​​​​

  • ​​​​​​​Caucasian male, 28 years old
  • Disease and treatment history: Worsening AD for 5–6 years, despite topical corticosteroids, TCI and phototherapy; occasional, mild keratitis, despite no longer wearing contact lenses.
  • Clinical assessment: EASI=26; 45% BSA (including the head and neck); persistent itching resulting in sleep deprivation; BMI 32
  • Personal impact: Daily life adversely affected: reluctant to leave the house, weight gain due to poor diet and little exercise, low self-esteem, ability to find employment negatively impacted.
Why consider Cibinqo (abrocitinib)?1. Cibinqo used in combination with topical therapy provides skin clearance at Week 12 in significantly more patients compared with placebo1,2JADE COMPARE (CO-PRIMARY ENDPOINTS, IN COMBINATION WITH MEDICATED TOPICAL THERAPY)Proportion of patients achieving IGA 0/1
Scroll left to view table
IGA 0/1 at Week 12 no./Total no. (%, 95% CI)
Cibinqo 200 mg 106/219 (48.8%; 41.8–55.0
Cibinqo 100 mg 86/235 (36.6%; 30.4–42.8)
Dupilumab 300 mg 88/241 (36.5%; 30.4–42.6)
Placebo 18/129 (14.0%; 8.0–19.9)

Analyses shown are between Cibinqo and placebo. Results are not to be interpreted as evidence of superiority, noninferiority, or similarity between Cibinqo and dupilumab.

Proportion of patients achieving EASI-75Example
Scroll left to view table
EASI-75 at Week 12 no./Total no. (%, 95% CI)
Cibinqo 200 mg 154/219 (70.3%; 64.3–76.4)
Cibinqo 100 mg 138/235 (58.7%; 52.4–65.0)
Dupilumab 300 mg 140/241 (58.1%; 51.9–64.3)
Placebo 35/129 (27.1%; 19.5–34.8)

Analyses shown are between Cibinqo and placebo. Results are not to be interpreted as evidence of superiority, noninferiority, or similarity between Cibinqo and dupilumab.

2. Cibinqo 200 mg provides superior itch response vs dupilumab at Week 21–3JADE COMPARE (KEY SECONDARY ENDPOINT, IN COMBINATION WITH MEDICATED TOPICAL THERAPY)Proportion of patients achieving PP-NRS4

PP-NRS4 is defined as an improvement of ≥4 points from baseline in the severity of PP-NRS. Cibinqo 200 mg was compared with dupilumab in the key secondary head-to-head endpoint, PP-NRS4 at Week 2. This endpoint was further analysed as prespecified multiplicity-controlled analysis and showed superiority to dupilumab down to Day 4. 

3. Cibinqo reduces AD-related sleep loss1,3JADE COMPARE (SECONDARY ENDPOINT, IN COMBINATION WITH MEDICATED TOPICAL THERAPY)% reduction (improvement) in SCORAD sleep loss subscale at Week 12

Change from baseline in SCORAD sleep loss is a prespecified secondary endpoint not controlled for multiplicity, therefore treatment differences could represent chance findings. 

​​​​​​​Analyses shown are between Cibinqo and placebo. Results are not to be interpreted as evidence of superiority, noninferiority, or similarity between Cibinqo and dupilumab.

Explore morePatient 2

Middle-aged mother with uncontrolled, severe eczematous lesions, resulting in selfconsciousness and anxiety.

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Patient 3

Young professional female with persistent, uncontrolled itching and lesions that are impacting her work.

View profile​​​​​​​​​​​​​​Loading

This patient profile is fictional and has been produced for the purposes of medical education. Any actual or potential likeness to real individuals is unintentional.​​​​​​​

AD=atopic dermatitis; BMI=body mass index; BSA=body surface area; CI​​​​​​​=confidence interval; EASI=Eczema Area and Severity Index; IGA=Investigator’s Global Assessment; LSM=least squares mean; PP-NRS=Peak Pruritus Numerical Rating Scale; SCORAD=SCORing Atopic Dermatitis; TCI=topical calcineurin inhibitor.

Prescribing information:
Cibinqo (abrocitinib) Prescribing Information (Great Britain) – 200 mg film-coated tablets.
Cibinqo (abrocitinib) Prescribing Information (Great Britain) – 100 mg film-coated tablets.
Cibinqo (abrocitinib) Prescribing Information (Great Britain) – 50 mg film-coated tablets.

References:

Cibinqo (abrocitinib) Summary of Product Characteristics.Bieber T, et al. N Engl J Med 2021;384(12):1101–1112.Bieber T, et al. N Engl J Med 2021;384(12):1101–1112. Supplementary appendix.
PP-CIB-GBR-0056. October 2021

Cibinqo Risk Minimisation Programme (RMP) materials, including a Patient Card and Prescriber Brochure, are available from https://www.medicines.org.uk/emc. Patients treated with Cibinqo should be given the Patient Card.

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store


Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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