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Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.

For the treatment of Invasive Aspergillosis and also for the treatment of Mucormycosis in patients for whom amphotericin B is inappropriate1

References:
  1. CRESEMBA Summary of Product Characteristics.
  2. Maertens JA, Raad II, Marr KA, et al. Isavuconazole versus voricanazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE); a phase 3, randomised-controlled, non-inferiority trial. Lancet. 2016;387(10020):760–769.
  3. Marty FM, Ostrosky-Zeichner L, Cornely OA, et al. Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. Lancet Infect Dis. 2016;16(7):828–837.

CRESEMBA® Mode of Action

CRESEMBA® contains the active substance isavuconazonium sulfate. Once hydrolysed into its active form, isavuconazole, it induces fungal cell death by inhibiting the production of fungal cell membrane components.

CRESEMBA® in Invasive Aspergillosis

The SECURE study was undertaken to compare the efficacy and safety of intravenous and oral formulations of isavuconazole to voriconazole for the primary treatment of invasive aspergillosis2.

Study Design

Efficacy

CRESEMBA® in Mucormycosis in patients for whom amphotericin B is inappropriate

The VITAL trial was undertaken to assess the efficacy and safety of isavuconazole for treatment of mucormycosis and to compare its efficacy with amphotericin B in a matched case-control analysis3.

Study Design

Efficacy

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Antifungal Stewardship

Discover resources designed to support you in adopting antifungal stewardship in your practice.

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Safety Profile

Understand more about the safety profile of CRESEMBA

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Dosing

Dosing recommendations for CRESEMBA

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Consider CRESEMBA® for the treatment of invasive aspergillosis and mucormycosis. For further information, contact your Pfizer representative

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​​​Prescribing Information for Cresemba (isavuconazole)

Great Britain
Cresemba (isavuconazole) 100mg hard capsules
Cresemba (isavuconazole) 200mg powder for concentrate for solution for infusion 

Northern Ireland
Cresemba (Isavuconazole) 100mg hard capsules and Cresemba (Isavuconazole) 200mg powder for concentrate for solution for infusion

Prescribing Information for Vfend (voriconazole)

Great Britain
​​​​​​​Vfend (voriconazole) 50mg film coated tablets
Vfend (voriconazole) 200mg film coated tablets
Vfend (voriconazole) 200mg powder for solution for infusion
Vfend (voriconazole) 40mg/ml powder for oral suspension

Northern Ireland
​​​​​​​Vfend (voriconazole): 50mg film coated tablets, 200mg film coated tablets, 200mg powder for solution for infusion & 40mg/ml powder for oral suspension 

References:
  1. CRESEMBA GB Summary of Product Characteristics.
  2. Maertens JA, Raad II, Marr KA, et al. Isavuconazole versus voricanazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE); a phase 3, randomised-controlled, non-inferiority trial. Lancet. 2016;387(10020):760–769.
  3. Marty FM, Ostrosky-Zeichner L, Cornely OA, et al. Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis. Lancet Infect Dis. 2016;16(7):828–837.
PP-CRB-GBR-1201. August 2021

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in Google Play or Apple App Store

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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PP-PFE-GBR-2688. December 2020

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