Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.
A diagnostic-driven approach to IFIs
A diagnostic approach to treating invasive fungal infections can aid early treatment of patients as well as improving the chances of survival1-4,6.
A diagnostic-driven approach allows early treatment (in neutropenic patients with or without fever)1-4
A combination of diagnostic assessments is recommended:5
- Monitoring of galactomannan (GM) may be used in patients who have a relatively high probability (>5-10%) of developing invasive aspergillosis (IA)
- Appropriate clinical and microbiological evaluation
- High-resolution computed tomography (CT) imaging
CT section of the lung with halo sign in a patient with haematological malignancy
Adapted from Green RE et al, 20076
A diagnostic-driven approach has the potential to help you improve patients' chances of survival6
- Routine GM screening is shown to lead to the early initiation of antifungal therapy4
- Initiating appropriate treatment on the basis of CT patterns has been shown to improve survival*6
- Increased survival was observed in patients with pulmonary invasive aspergillosis who presented with a halo sign versus those with other imaging findings at Week 12: 71% vs 53%, respectively (p<0.01)6
*Based on analysis of chest CT findings at presentation from a large series (n=235) of patients with invasive pulmonary aspergillosis (IPA), to assess the prevalence of a "halo sign" and to evaluate the clinical utility of this imaging finding for early identification and treatment of IPA6
Example of a diagnostic-driven antifungal therapy integrated care pathway7
Image based on Agrawal S, et al. J Antimicrob Chemother. 2011; 66(Suppl 1): i45-53.
*Check response on Day 7. If no response to treatment, further diagnosis is required; if patient responds to treatment, consider the duration of therapy, "step down" therapy, and outpatient follow up.
†Multidisciplinary team input important at this stage.
IFD, invasive fungal disease; IMD, invasive mould disease; PCR, polymerase chain reaction
Prescribing Information for Cresemba (isavuconazole)
Great Britain
Cresemba (isavuconazole) 100mg hard capsules
Cresemba (isavuconazole) 200mg powder for concentrate for solution for infusion
Northern Ireland
Cresemba (Isavuconazole) 100mg hard capsules and Cresemba (Isavuconazole) 200mg powder for concentrate for solution for infusion
- Rogers TR, et al. Br J Haematol. 2011; 153(6): 681–97.
- Freemantle N, et al. J Antimicrob Chemother. 2011; 66(Suppl 1): i25–35.
- de Pauw BE& Viscoli C. J Antimicrob Chemother. 2011; 66(Suppl 1): i55–8.
- Maertens J, et al. Clin Infect Dis. 2005; 41(9): 1242–50.
- Marchetti O et al. Bone Marrow Transplant. 2012; 47(6): 846–54.
- Greene RE, et al. Clin Infect Dis. 2007; 44(3): 373–9.
- Agrawal S, et al. J Antimicrob Chemother. 2011; 66(Suppl 1): i45-53.
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Antifungal Stewardship: Diagnostics Summary.
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Learn about aspergillosis lateral flow tests
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Invasive aspergillosis and the ICU
Underlying conditions in ICU patients
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