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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.

Primary endpoint1


  • All-cause mortality from first dose of study drug to Day 42 in the ITT population​​​​​​​

Secondary endpoints


  • Overall response at end of treatment in the mITT population

Other Secondary endpoints:

  • All-cause mortality from first dose of study drug to Day 84
  • Overall clinical, mycological and radiological responses on Day 42, 84 and end of treatment
  • Safety
  • Tolerability

* Hepatic dysfunction (bilirubin ≥3 × ULN, alanine transaminase or aspartate transaminase ≥5 × ULN, cirrhosis or chronic hepatic failure), or moderate-to-severe renal dysfunction (calculated creatinine clearance <50 mL/min). †As assessed by the data review committee. ITT, intention-to-treat; IV, intravenous; mITT, modified intention-to-treat; PO, orally; q8h, every 8 hours; q12h, every 12 hours; q24h every 24 hours; ULN- upper limit of normal

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  1. ​​​​​​​Maertens JA, Raad II, Marr KA, et al. Isavuconazole versus voricanazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE); a phase 3, randomised-controlled, non-inferiority trial. Lancet. 2016;387(10020):760–769.
PP-CRB-GBR-1202. August 2021

Invasive Aspergillosis (Quick Links)

Safety Profile

 CRESEMBA safety information

For UK Healthcare Professionals*

These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.

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*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.

PP-PFE-GBR-3863. November 2021



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