Invasive aspergillosis and mucormycosis represent a serious additional threat to COVID-19 patients who develop ARDS or are admitted to the ICU.1–5 Cases of COVID-19-associated pulmonary aspergillosis (CAPA) and COVID-19-associated mucormycosis (CAM) are increasingly being reported,6 with an overall prevalence among ICU patients of 9.3%7 and 1.6%8, respectively.
How many critically ill patients develop invasive aspergillosis in the ICU?a
a. Cases of invasive aspergillosis (mainly pulmonary) reported among ICU patients in different prospective and retrospective studies.
Some potential risk factors predisposing COVID-19 patients to secondary invasive fungal infections have been identified:1,7,8,15–18
Risk factors for invasive fungal infections in the ICU
Effective management of CAPA and CAM requires prompt diagnosis, treatment of underlying diseases, and aggressive medical intervention.1,19-21 However, clinical and radiological signs of CAPA and CAM can overlap – and there have been reports of simultaneous mixed superinfection – which may complicate the diagnosis.5,6,22
While there are several approved treatments for invasive aspergillosis and mucormycosis, an individualised assessment should be considered for every patient, taking into account differences in coverage, tolerability, drug interaction profile, and PK.23-26
CRESEMBA® can offer the flexibility you need, so that you can focus on your patient’s underlying condition23,33,34,37
Support & Resources
Meet Anika, our hypothetical ICU patient with suspected COVID-19-associated invasive aspergillosis
Meet Sanjay, our hypothetical ICU patient with suspected COVID-19-associated mucormycosis
These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
I confirm that I am a healthcare professional* resident in the United Kingdom.
If you select 'No', you will be redirected to Pfizer.co.uk where you will be able to access reference information on Pfizer's prescription medicines.
*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.
PP-PFE-GBR-3863. November 2021
OK, We will need you to sign in before we can determine if you are aligned with a Pﬁzer promotional colleague.This is an interstitial message to prompt a HCP before they login.
If you have already registered with pfizerpro.co.uk and select ‘yes’, you will be directed to the sign-in page where you will be required to enter your username and password.
Would you like to register or sign in now?