Invasive aspergillosis and mucormycosis represent a serious additional threat to COVID-19 patients who develop ARDS or are admitted to the ICU.1–5 Cases of COVID-19-associated pulmonary aspergillosis (CAPA) and COVID-19-associated mucormycosis (CAM) are increasingly being reported,6 with an overall prevalence among ICU patients of 9.3%7 and 1.6%8, respectively.
How many critically ill patients develop invasive aspergillosis in the ICU?a
a. Cases of invasive aspergillosis (mainly pulmonary) reported among ICU patients in different prospective and retrospective studies.
Some potential risk factors predisposing COVID-19 patients to secondary invasive fungal infections have been identified:1,7,8,15–18
Risk factors for invasive fungal infections in the ICU
Effective management of CAPA and CAM requires prompt diagnosis, treatment of underlying diseases, and aggressive medical intervention.1,19-21 However, clinical and radiological signs of CAPA and CAM can overlap – and there have been reports of simultaneous mixed superinfection – which may complicate the diagnosis.5,6,22
While there are several approved treatments for invasive aspergillosis and mucormycosis, an individualised assessment should be considered for every patient, taking into account differences in coverage, tolerability, drug interaction profile, and PK.23-26
CRESEMBA® can offer the flexibility you need, so that you can focus on your patient’s underlying condition23,33,34,37
Safety Profile
Support & Resources
Meet Anika, our hypothetical ICU patient with suspected COVID-19-associated invasive aspergillosis
Meet Sanjay, our hypothetical ICU patient with suspected COVID-19-associated mucormycosis
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