This site contains promotional information intended only for healthcare professionals resident in the United Kingdom
Sign in
Sign In or Register
Sign out

Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

See all Therapy areas

Explore Content

Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.

Invasive Aspergillosis and the ICU

Invasive aspergillosis is a serious opportunistic infection associated with extremely high mortality.1 It typically affects individuals who are severely immunocompromised and/or have well-established risk factors, which may be related to:2-5​​​​​​​

Overall, the majority of patients that contract the infection have a haematological malignancy as an underlying condition (>50% of cases).Looking specifically at the ICU patient population, however, information about the epidemiology of invasive aspergillosis is scarce, but data are emerging for this particular and unique setting.4

Unusual suspects

In addition to immunocompromised patients, it has become clear in recent years that Aspergillus species can cause invasive disease in less traditional categories of hosts for whom clinical risk factors are less defined, including critically ill patients admitted to the ICU.2–4,7 These patients may be mildly immunocompromised due to non-malignant conditions,8 or even have no immunosuppression or underlying diseases at all.3 As such, they may fall outside the standard EORTC/MSG definitions for invasive fungal disease,9 making the diagnosis of invasive aspergillosis a real challenge.4 In particular, invasive aspergillosis is a common complication of severe influenza in the ICU, affecting ~20% of patients.10,11

Underlying conditions in ICU patients with invasive aspergillosis (n=297)4

Key Facts about the ICU7,10,11​​​​​​​

Explore more

Invasive Aspergillosis

An overview of the SECURE trial for CRESEMBA (isavuconazole)

The SECURE trial


An overview of the VITAL trial for CRESEMBA (isavuconazole)

The VITAL trial


​​​​​​​​​​​​​​ ARDS, acute respiratory distress syndrome; BMT, bone marrow transplant; COPD, chronic obstructive pulmonary disease; EORTC/MSG, European Organization for Research and Treatment of Cancer/Mycosis Study Group; HIV, human immunodeficiency virus; ICU, intensive care unit; TNF, tumour necrosis factor.

  1. Lin SJ et al. Clin Infect Dis 2001;32(3):358–366.
  2. Bassetti M et al. Infect Dis Ther 2018;7(1):17–27. ECDC. Influenza-associated invasive pulmonary. 
  3. aspergillosis, Europe. 2018. Available from: Accessed October 2020.
  4. Taccone FS et al. Crit Care 2015;19:7. 
  5. Baddley JW. Med Mycol 2011;49 Suppl 1:S7–S12.
  6. Cornillet A et al. Clin Infect Dis 2006;43(5):577–584. 
  7. Bassetti M et al. IDCases 2018;12:7–9.
  8. Delsuc C et al. Crit Care 2015;19:421. 
  9. De Pauw B et al. Clin Infect Dis 2008;46(12):1813–1821.
  10. Schauwvlieghe A et al. Lancet Respir Med. 2018;6(10):782–792. 
  11. Wauters J et al. Intensive Care Med 2012;38(11):1761–1768.
PP-CRB-GBR-1212. August 2021

Safety and Tolerability (Quick Links)

A diagnostic driven approach

How to approach diagnostics


 Find out more

For UK Healthcare Professionals*

These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.

I confirm that I am a healthcare professional* resident in the United Kingdom.

If you select 'No', you will be redirected to where you will be able to access reference information on Pfizer's prescription medicines.

*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.

PP-PFE-GBR-3863. November 2021



OK, We will need you to sign in before we can determine if you are aligned with a Pfizer promotional colleague.This is an interstitial message to prompt a HCP before they login.

If you have already registered with and select ‘yes’, you will be directed to the sign-in page where you will be required to enter your username and password.

Would you like to register or sign in now?