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Pfizer MedicinesTherapy AreasExplore ContentEventsVideosMaterialsFeatured ArticlesLet’s ConnectSupplyAlliance HealthcareOff-contract claims

Adverse event reporting can be found at the bottom of the page

About DOSTINEXDosing & Administration  EfficacySafetySupport and Resources Materials Videos 

Dostinex (cabergoline) Prescribing Information (external link) Adverse event reporting information can be found at the bottom of the page 

DOSTINEX is generally well tolerated1-3

In clinical trials, most side effects were mild to moderate while taking DOSTINEX.2,3

The most common side effects experienced included nausea, headache and dizziness.1-3

Significantly fewer patients taking DOSTINEX discontinued treatment due to intolerance vs bromocriptine (p<0.001)1Patient discontinuations1


Full list of adverse events:4

The following undesirable effects have been observed and reported during treatment with DOSTINEX with the following frequencies: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to ≤1/100); rare (≥1/10,000 to≤1/1,000); very rare (≤1/10,000), not known (cannot be estimated from the available data)1

Example

Example

* Very common in patients treated for hyperprolactinaemia disorders; common in patients treated for inhibition/suppression of lactation.
** Common in patients treated for hyperprolactinaemia disorders; uncommon in patients treated for inhibition/suppression of lactation.
*** Very common in patients treated for hyperprolactinaemia disorders; uncommon in patients treated for inhibition/suppression of lactation.

Contraindications4

Patients with these conditions should not take DOSTINEX:

Hypersensitivity to cabergoline, any of the excipients listed in Dostinex (cabergoline) Prescribing Information, or any ergot alkaloid

History of pulmonary, pericardial and retroperitoneal fibrotic disorders

Cabergoline is contraindicated in patients with hepatic insufficiency and with toxaemia of pregnancy

Cabergoline should not be co-administered with anti-psychotic medications or administered to women with a history of puerperal psychosis.

For long-term treatment: Evidence of cardiac vulvulopathy as determined by pretreatment echocardiography

See Dostinex (cabergoline) Prescribing Information for Special warnings and precautions for use.

References:Webster J, et al. A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group. N Engl J Med 1994;331(14):904-909.Webster J, et al. Dose-dependent suppression of serum prolactin by cabergoline in hyperprolactinaemia: a placebo controlled, double blind, multicentre study. European Multicentre Cabergoline Dose-finding Study Group. Clin Endocrinol (Oxf) 1992;37(6):534-541.European Multicentre Study Group for Cabergoline in Lactation Inhibition. Single dose cabergoline versus bromocriptine in inhibition of puerperal lactation: randomised, double blind, multicentre study. BMJ 1991;302:1367-1371.Dostinex [summary of product characteristics]. Sandwich, Kent; Pfizer Limited; 2020.  
Download a patient leaflet for "How to Prepare for a Prolactin Test"View DOSTINEX materials hereLoadingAbout Dostinex

Explore more including a snapshot of DOSTINEX and a video explaining how DOSTINEX works to lower prolactin levels

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Dosing and administration

Learn more about the dosing for DOSTINEX

Learn moreLoading
EfficacyView clinical trial data to show proven efficacy in hyperprolactinaemia & lactation suppression with DOSTINEX Learn moreLoading
PP-DOS-GBR-0016. July 2023

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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