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The content of this website has been produced in line with the ELREXFIO®▼ (elranatamab) Summary of Product Characteristics. For Elrexfio®▼ (elranatamab) Prescribing Information for United Kingdom click here.
MagnetisMM-3 Study Design and Baseline Demographics
MagnetisMM-3 (trial ongoing) is an open-label, global, multicentre, non-randomised Phase 2 study evaluating ELREXFIO® monotherapy in patients with relapsed or refractory multiple myeloma (RRMM), refractory to at least 1 proteasome inhibitor (PI), 1 immunomodulatory drug (IMiD), and 1 anti-CD38 monoclonal antibody.1
The primary endpoint is objective response rate (ORR) as assessed by blinded independent central review (BICR). Key secondary endpoints include: minimal residual disease (MRD) negativity rate (10-5), time to response (TTR), duration of response (DoR), progression-free survival (PFS), complete response rate (CRR), and safety.1
Adapted from ELREXFIO® Summary of Product Characteristics.1
*The dosing interval was changed from QW to Q2W in patients who achieved an IMWG response category of partial response or better with responses persisting for at least 2 months.1
Patient demographics and key prognostic factors for MM1,2
| BCMA-directed therapy-naïve (n=123) | |
|---|---|
| Median age (range), years | 68.0 (36-89) |
| Male, n (%) | 68 (55.3) |
| Female, n (%) | 55 (44.7) |
| Race, n (%) | |
| White Asian Hispanic/Latino Black or African American |
72 (58.5) 16 (13.0) 11 (8.9) 9 (7.3) |
| Extramedullary disease,* n(%) | 39 (31.7) |
| High cytogenic risk,† n(%) | 31 (25.2) |
| Revised International Staging System (R-ISS stage), n(%) | |
| I II III |
28 (22.8) 68 (55.3) 19 (15.4) |
| Median lines of prior therapy, n (range) | 5 (2-22) |
| Triple-class refractory, n (%) | 119 (96.7) |
| Refractory to last line of therapy, n (%) | 118 (95.9) |
| Prior allogenic stem cell transplantation, n (%) | 7 (5.7) |
| Prior autologous stem cell transplantation, n (%) | 84 (68.3) |
Adapted from ELREXFIO® Summary of Product Characteristics and Pfizer Data on File. REF-E1A2136.1
Please note that percentages may not total 100 due to rounding.
*Defined as the presence of any plasmacytoma (extramedullary and/or paramedullary with a soft tissue component).1
†Includes the following chromosomal abnormalities: t(4;14), t(14;16), and del(17p).1
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