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Information on how to access Fragmin® (dalteparin sodium) prescribing information and adverse event reporting can be found at the bottom of the page.

Dosing: Peri and Post -Operative

Surgical thromboprophylaxis

Use Fragmin for peri- and post- operative surgical thromboprophylaxis

Surgery carries with it various risks, one of which is venous thromboembolism (VTE). VTE during the hospital stay affects approximately 60% of patients undergoing hip replacement surgery1

Indication:

Thromboprophylaxis in moderate and high-risk surgical patients and prolonged thromboprophylaxis in hip replacement surgery2

Dosage:

Use Fragmin single dose syringes: 2,500 IU/5,000 IU dalteparin sodium2

Moderate risk of thrombosis:

2,500 IU s.c. 1–2 hours before surgery
Continue 2,500 IU s.c. each morning, until the patient is mobilised, in general for 5–7 days or longer

High risk of thrombosis:

2,500 IU s.c. 1–2 hours before surgery, then 2,500 IU s.c. 8–12 hours later. Continue 5,000 IU s.c. each morning, until the patient is mobilised, in general for 5–7 days or longer

Alternatively:

5,000 IU s.c. the evening before surgery. Continue 5,000 IU s.c. the following evenings until the patient is mobilised, in general for 5–7 days or longer

​​​​​​​Prolonged thromboprophylaxis in hip replacement surgery:

5,000 IU s.c. the evening before surgery. Continue 5,000 IU s.c. each evening for 5 post-operative weeks

If pre-operative administration of Fragmin is not considered appropriate because the patient is at high risk of haemorrhage during the procedure, post-operative Fragmin may be administered

Peri- and Post-operative Surgical Thromboprophylaxis

Fragmin Tolerability

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PP-PFE-GBR-2688. December 2020

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