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Information on how to access Fragmin® (dalteparin sodium) prescribing information and adverse event reporting can be found at the bottom of the page.

Dosing: Treatment of Venous Thromboembolism (VTE)

Use of Fragmin for the treatment of VTE1


Treatment of venous thromboembolism (VTE) presenting clinically as deep vein thrombosis (DVT), pulmonary embolism (PE) or both1


A single dose of Fragmin is administered subcutaneously, once daily according to the following weight ranges (monitoring of the anticoagulant effect is not usually necessary):1

Prefilled Syringes:

The single daily subcutaneous dosage should not exceed 18,000 IU

In case of overdose the recommneded dosage of protamine is 1mg of protamine/100 IU Fragmin


** The single daily dose should not exceed 18,000 IU.
≈ Monitoring of the treatment is generally not necessary but can be performed with a functional anti-Factor Xa assay. Maximum plasma levels are obtained 3–4 hours after sc. injection, when samples should be taken. Recommended plasma levels are between 0.5–1.0 IU (anti-Factor Xa)/ml.

Simultaneous anticoagulation with oral VKAs (vitamin K antagonists) can start immediately1

Treatment with Fragmin is continued until the prothrombin complex levels (Factor II, VII, IX, X) have decreased to a therapeutic level1

At least 5 days of combined treatment is normally required1

Treatment of VTE

Fragmin Tolerability

Find out more

Using Fragmin Needle-Trap

Click below to learn how to use a Fragmin Needle-Trap

Learn more

For UK Healthcare Professionals*

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PP-PFE-GBR-3863. November 2021



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