Information on how to access Fragmin® (dalteparin sodium) prescribing information and adverse event reporting can be found at the bottom of the page.
Use of Fragmin for the treatment of VTE1
Treatment of venous thromboembolism (VTE) presenting clinically as deep vein thrombosis (DVT), pulmonary embolism (PE) or both1
A single dose of Fragmin is administered subcutaneously, once daily according to the following weight ranges (monitoring of the anticoagulant effect is not usually necessary):1
The single daily subcutaneous dosage should not exceed 18,000 IU
In case of overdose the recommneded dosage of protamine is 1mg of protamine/100 IU Fragmin
** The single daily dose should not exceed 18,000 IU.
≈ Monitoring of the treatment is generally not necessary but can be performed with a functional anti-Factor Xa assay. Maximum plasma levels are obtained 3–4 hours after sc. injection, when samples should be taken. Recommended plasma levels are between 0.5–1.0 IU (anti-Factor Xa)/ml.
Simultaneous anticoagulation with oral VKAs (vitamin K antagonists) can start immediately1
Treatment with Fragmin is continued until the prothrombin complex levels (Factor II, VII, IX, X) have decreased to a therapeutic level1
At least 5 days of combined treatment is normally required1
Prescribing Information
Fragmin (dalteparin sodium) 10,000 IU/0.4ml solution for injection
Fragmin (dalteparin sodium) 10,000 IU/1 ml solution for injection
Fragmin (dalteparin sodium) 10,000 IU/4ml solution for injection
Fragmin (dalteparin sodium) 100,000 IU / 4ml Multidose Vial solution for injection
Fragmin (dalteparin sodium) 12,500 IU/0.5ml solution for injection
Fragmin (dalteparin sodium) 15,000 IU/0.6ml solution for injection
Fragmin (dalteparin sodium) 18,000 IU/0.72ml solution for injection
Fragmin (dalteparin sodium) 2500 IU solution for injection
Fragmin (dalteparin sodium) 5000 IU solution for injection
Fragmin (dalteparin sodium) 7,500 IU/0.3 ml solution for injection
Fragmin (dalteparin sodium) Graduated Syringe 10,000 IU/ml Solution for Injection
Click below to learn how to use a Fragmin Needle-Trap
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PP-PFE-GBR-3863. November 2021
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