This site contains promotional information intended only for healthcare professionals resident in the United Kingdom
Sign in
Sign In or Register
Sign out

Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

See all Therapy areas

Explore Content

Information on how to access Fragmin® (dalteparin sodium) prescribing information and adverse event reporting can be found at the bottom of the page.

Dosing: Treatment of Venous Thromboembolism (VTE)

Use of Fragmin for the treatment of VTE1

Indication:

Treatment of venous thromboembolism (VTE) presenting clinically as deep vein thrombosis (DVT), pulmonary embolism (PE) or both1

Dosage:

A single dose of Fragmin is administered subcutaneously, once daily according to the following weight ranges (monitoring of the anticoagulant effect is not usually necessary):1

Prefilled Syringes:

The single daily subcutaneous dosage should not exceed 18,000 IU

In case of overdose the recommneded dosage of protamine is 1mg of protamine/100 IU Fragmin

Ampoules:

** The single daily dose should not exceed 18,000 IU.
≈ Monitoring of the treatment is generally not necessary but can be performed with a functional anti-Factor Xa assay. Maximum plasma levels are obtained 3–4 hours after sc. injection, when samples should be taken. Recommended plasma levels are between 0.5–1.0 IU (anti-Factor Xa)/ml.

Simultaneous anticoagulation with oral VKAs (vitamin K antagonists) can start immediately1

Treatment with Fragmin is continued until the prothrombin complex levels (Factor II, VII, IX, X) have decreased to a therapeutic level1

At least 5 days of combined treatment is normally required1

Treatment of VTE

Fragmin Tolerability

Find out more

Using Fragmin Needle-Trap

Click below to learn how to use a Fragmin Needle-Trap

Learn more

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in Google Play or Apple App Store

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

For UK Healthcare Professionals*

These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.

I confirm that I am a healthcare professional* resident in the United Kingdom.

If you select 'No', you will be redirected to Pfizer.co.uk where you will be able to access reference information on Pfizer's prescription medicines.

*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.

PP-PFE-GBR-3863. November 2021

Yes

No

OK, We will need you to sign in before we can determine if you are aligned with a Pfizer promotional colleague.This is an interstitial message to prompt a HCP before they login.

If you have already registered with pfizerpro.co.uk and select ‘yes’, you will be directed to the sign-in page where you will be required to enter your username and password.

Would you like to register or sign in now?