Information on how to access Fragmin® (dalteparin sodium) prescribing information and adverse event reporting can be found at the bottom of the page.
Renal impairment is common in hospitalised patients1,2
As can be seen in the pie chart above, a quarter of medical inpatients have some degree of renal impairment (Stage ≥3).1,2
In one study, compared with LMWH, initial VTE treatment with UFH in patients with severe renal impairment (CrCl <30 ml/min) resulted in:3
While patients with VTE who have renal insufficiency are at higher risk of both fatal bleeding and fatal pulmonary embolism (PE)4, an analysis of this group found the risk of fatal PE far exceeded the risk of fatal bleeding.5
A post hoc analysis of the CLOT study found high-dose, extended treatment with Fragmin significantly reduced the risk of recurrent VTE in cancer patients with renal impairment. Compared with VKA, Fragmin significantly reduced risk of recurrent VTE in patients with cancer and renal impairment (p=0.01) while exhibiting a comparable safety profile.6
The advantages of VTE treatment with LMWH compared with UFH in renal impairment7–11
More predictable anticoagulant response7,8
Better bioavailability at low doses7,8
Dose-independent clearance mechanism7
Longer half-life7,8
Lower incidence of bleeding complications8
Lower incidence of heparin-induced thrombocytopenia (HIT)8,9
Decreased tendency to produce osteopenia on prolonged administration10
Ease of administration8,11
No daily anticoagulation monitoring in the majority of patients8
Outpatient use8
LMWHs are not clinically interchangeable11
LMWH = low-molecular-weight heparin; PE= pulmonary embolism; UFH = unfractioned heparin; VKA = vitamin K antagonists; VTE = venous thromboembolism;
Prescribing Information
Fragmin (dalteparin sodium) 10,000 IU/0.4ml solution for injection
Fragmin (dalteparin sodium) 10,000 IU/1 ml solution for injection
Fragmin (dalteparin sodium) 10,000 IU/4ml solution for injection
Fragmin (dalteparin sodium) 100,000 IU / 4ml Multidose Vial solution for injection
Fragmin (dalteparin sodium) 12,500 IU/0.5ml solution for injection
Fragmin (dalteparin sodium) 15,000 IU/0.6ml solution for injection
Fragmin (dalteparin sodium) 18,000 IU/0.72ml solution for injection
Fragmin (dalteparin sodium) 2500 IU solution for injection
Fragmin (dalteparin sodium) 5000 IU solution for injection
Fragmin (dalteparin sodium) 7,500 IU/0.3 ml solution for injection
Fragmin (dalteparin sodium) Graduated Syringe 10,000 IU/ml Solution for Injection
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