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Prescribing Information for Genotropin® (somatropin) can be found here. Adverse event reporting information can be found at the bottom of the page.

Growth Hormone Deficient Adults1Genotropin (somatropin) is indicated for patients with pronounced adult-onset growth hormone deficiency who:
  • Have severe growth hormone deficiency associated with multiple hormone deficiencies as a result of known hypothalamic or pituitary pathology.
  • Who have at least one known deficiency of a pituitary hormone other than prolactin.
These patients should undergo an appropriate dynamic test in order to diagnose or exclude a growth hormone deficiency.Genotropin® is indicated for childhood-onset patients who:
  • Have been growth hormone deficient during childhood as a result of congenital, genetic, acquired, or idiopathic causes.
  • Patients with childhood onset GHD should be re-evaluated for growth hormone secretory capacity after completion of longitudinal growth.
  • In patients with a high likelihood for persistent GHD (Growth Hormone Deficiency), i.e. a congenital cause or GHD secondary to a pituitary/hypothalamic disease or insult, an insulin-like growth factor-I (IGF-I) SDS (Standard Deviation Score) < - 2 off growth hormone treatment for at least 4 weeks should be considered sufficient evidence of profound GHD.
All other patients will require IGF-I assay and one growth hormone stimulation test.DosingDosing
For full details regarding dosing please refer to the Summary of Product Characteristics.

Example

For full details regarding dosing please refer to the Summary of Product Characteristics.


Women may require higher doses than men, with men showing an increasing IGF-I sensitivity over time. This means that there is a risk that women, especially those on oral oestrogen replacement are under-treated while men are over-treated. The accuracy of the growth hormone dose should therefore be controlled every 6 months.

* Clinical response and side effects may also be used as guidance for dose titration. Some patients with GHD do not normalise IGF-I levels despite a good clinical response, and therefore do not require dose escalation.
† For patients with normal IGF-I concentrations at the start of the treatment, GH should be administered up to an IGF-I level into upper range of normal,
not exceeding 2 SDS from the age-corrected mean.
Reference:GENOTROPIN Summary of Product Characteristics: https://www.medicines.org.uk/emc/search?q=Genotropin
PP-GEN-GBR-1608. January 2023

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for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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