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HomeMechanism of ActionEfficacySafetyDosingHow HYMPAVZI WorksHow HYMPAVZI WorksHYMPAVZI OverviewHow HYMPAVZI WorksEfficacyEfficacyStudy DesignPrimary EndpointLong-term ProtectionSecondary EndpointsSafetySafetyAdverse EventsSafetyDosingDosingDosing OverviewMeet the HYMPAVZI PenInjection OverviewWhy HYMPAVZIWhy HYMPAVZIAddresing Patient NeedsWhy HYMPAVZIResourcesResourcesMaterialsVideos

Click here for HYMPAVZI®▼ (marstacimab) Prescribing Information.

In the BASIS study and OLE, HYMPAVZI was generally well tolerated in patients with severe haemophilia A or B without inhibitors aged 12 years and older who weighed at least 35kg1

The data reflects exposure of 116 patients to HYMPAVZI administered once weekly. The safety analysis also includes data from the 87 patients who went on to enrol in the OLE study. Medium duration of exposure was 518.5 days (range 28-847 days).1

Adverse reactions from the BASIS study and the OLE study1
Adverse reactionFrequency
HeadacheCommon (≥1/100 to <1/10)
HypertensionCommon (≥1/100 to <1/10)
RashUncommon (≥1/1000 to <1/100)
PruritusCommon (≥1/100 to <1/10)
Injection site reactionsVery common (≥1/10)
In the BASIS study and OLE, 11.2% of patients treated with HYMPAVZI reported injection site reactions.The majority of injection site reactions observed in clinical studies with HYMPAVZI are reported as mild to moderate, and do not lead to dose adjustment or discontinuation.1*

*Injection site reactions include injection site bruising, injection site erythema, injection site haematoma, injection site induration, injection site oedema, injection site pain, injection site pruritus, and injection site swelling.1

OLE, open-label extension.

References:

1. HYMPAVZI (marstacimab) Summary of Product Characteristics.Kicker Header of this card goes here

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Optional footnote area for disclaimers etc.

The efficacy of HYMPAVZI was evaluated in the BASIS study

Learn more about HYMPAVZI efficacy.

 EfficacyLoadingPre-filled fixed dose pen. Once-weekly dosing1

Understand the HYMPAVZI dosing schedule and see how HYMPAVZI can be administered.

 DosingLoading
PP-HYM-GBR-0122. June 2025

Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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