The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain. IBRANCE® (palbociclib) Prescribing Information for Great Britain click here. IBRANCE® (palbociclib) Prescribing Information for Northern Ireland click here. Adverse event reporting information can be found at the bottom of the page.
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Confidence Built on Evidence1
Dosing and monitoring requirements for IBRANCE®
IBRANCE® PALOMA-2 and PALOMA-3 Clinical Trial Results, including efficacy and safety outcomes
Important safety information and safety outcomes from IBRANCE® PALOMA Clinical Trials
IBRANCE® (palbociclib) is indicated for the treatment of HR+/HER2- locally advanced or mBC in combination with an AI or with fulvestrant in women who have received prior ET. In pre- or peri-menopausal women, the ET should be combined with an LHRH agonist.1
IBRANCE® is the first cyclin-dependent kinase 4/6 (CDK4/6) inhibitor approved for HR+/HER2- locally advanced and metastatic breast cancer.1-2
As a 1st line therapy in HR+/HER2- locally advanced and metastatic breast cancer, IBRANCE® + letrozole has demonstrated >2 years median progression free survival vs letrozole plus placebo alone in the PALOMA-2 study.2-3 IBRANCE® plus fulvestrant delivers more than double the mPFS compared with fulvestrant monotherapy, 11.2 months with IBRANCE® plus fulvestrant vs. 4.6 months with fulvestrant plus placebo.4-5
Real-world evidence for IBRANCE® (palbociclib) in advanced Breast Cancer
IBRANCE® (palbociclib) Resources to support your patients including a Patient Brochure and Dosing Cards
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.
These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
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PP-PFE-GBR-2688. December 2020