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Pfizer MedicinesTherapy AreasExplore ContentEventsVideosMaterialsFeatured ArticlesLet’s ConnectSupplyAlliance HealthcareOff-contract claims

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DosingDosingIBRANCE® Dosing
 
Monitoring Requirements
SafetySafetyIBRANCE® Safety ProfileNeutropeniaAdverse Event ManagementClinical Trials
Clinical TrialsIBRANCE® Clinical TrialsIBRANCE® PALOMA-2 Trial
 
IBRANCE® PALOMA-3 Trial
Real World EvidenceReal World EvidenceIBRANCE® Real World EvidenceIRIS (UK) StudyROIS
 
P-REALITY X
Patient ProfilesThe Ibrance® PatientPatient ProfilesAlison - >65 years with comorbiditiesBecky - Postmenopausal with bone-only diseaseSupport and ResourcesSupport and ResourcesIBRANCE Service SupportMaterials
 
Videos

The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain and Northern Ireland. IBRANCE® (palbociclib) Prescribing Information for Great Britain and Northern Ireland click here.  Adverse event reporting information can be found at the bottom of the page.

IBRANCE® (palbociclib) is indicated for the treatment of HR+ HER2- locally advanced or metastatic breast cancer in combination with an AI, or in combination with fulvestrant in women who have received prior endocrine therapy. In pre- or perimenopausal women, the endocrine therapy should be combined with a LHRH agonist.1
Clinical Trials

Confidence in a Treatment that’s setting the standard4-6

The efficacy and safety of IBRANCE® has been evaluated in two large Randomised Control Trials (RCTs) in women with HR+/HER2- metastatic Breast Cancer (mBC) as part of Pfizer’s robust PALOMA Clinical Trial Programme in Breast Cancer.2-6

PALOMA Clinical Trials Programme
PALOMA-2 Trial

IBRANCE® + Aromatase Inhibitor (AI) PALOMA-2 Clinical Trial results including efficacy and safety outcomes.

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PALOMA-3 Trial

IBRANCE® + Fulvestrant (FUL) PALOMA-3 Clinical Trial results including efficacy and safety outcomes.

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IBRANCE® Real World Evidence

Real World Evidence (RWE) for IBRANCE® (pabociclib) in advanced breast cancer

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IBRANCE® Safety Profile

IBRANCE® safety information and frequent adverse events
 

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AI : Aromatase Inhibitor, ER+ / HER2− : Oestrogen Receptor-Positive / Human Epidermal Growth Factor Receptor 2-Negative, ET : Endocrine Therapy, HR+ / HER2- : Hormone Receptor-Positive / Human Epidermal Growth Factor Receptor 2-Negative, LHRH : Luteinising Hormone-Releasing Hormone, mBC : metastatic Breast Cancer, RCT: Randomised Controlled Trial, SmPC: Summary of Product Characteristics.

References

IBRANCE® Summary of Product Characteristics for Great Britain click here. IBRANCE® Summary of Product Characteristics for Northern Ireland click here.Rugo HS, et al. Breast Cancer Res Treat. 2019;174:719–29.Finn RS, et al. N Engl J Med. 2016;375(20):1925-1936.Cristofanilli M, et al. Lancet Oncol. 2016;17(4):425-439. Cristofanilli M, et al. ECJ 2018;104:21-31.Turner NC, et al. N Engl J Med 2018;379:1926–1936 including supplementary appendix.
PP-IBR-GBR-5604. January 2024

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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