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Confidence in a Treatment that's Setting the Standard1-2
The growth of HR+ breast cancer is dependent on cyclin D1, a direct transcriptional target of the ER3-4
a. Cyclin D1 activates CDK4/6 resulting in G1–S phase transition and entry into the cell cycle3-4
b. Cell-line models of endocrine resistance remain dependent on cyclin D1 and CDK4/63-4
IBRANCE® is an orally active selective inhibitor of CDK4 and CDK6 kinases.5-6
IBRANCE® blocks Rb phosphorylation at concentrations of 9–15 nmol/l, inducing G1 arrest in Rb+ tumour cell lines.5
Synergy between ER and CDK4/6 has led to IBRANCE® being developed in combination with endocrine therapy as treatment for HR+/HER2- mBC.6
Adapted from Cadoo KA, et al. Breast Cancer Targets and Therapy. 2004;6:123–33.4
ER : Oestrogen Receptor, HR+ : Hormone Receptor Positive, HER2- : Human Epidermal growth factor Receptor 2-negative, mBC : metastatic Breast Cancer
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IBRANCE® safety information and outcomes
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