The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain and Northern Ireland. IBRANCE® (palbociclib) Prescribing Information for Great Britain and Northern Ireland click here. Adverse event reporting information can be found at the bottom of the page.
Confidence without Compromise1-2
The PALOMA-2 study shows that you can offer your patients efficacy without compromising QoL with IBRANCE® in combination with letrozole.1
Patient-reported health-related QOL (HRQOL) outcomes was a secondary objective in the PALOMA-2 trial.
A post-hoc analysis of median TTD in FACT-B scores showed a positive trend favouring IBRANCE® + letrozole vs placebo + letrozole (HR: 0.883; P=0.1900).1*
The difference did not reach statistical significance.1
Adapted from Rugo HS, et al. Ann Oncol. 2018;29:888-94.1
* In a population of post-menopausal women with ER+/HER2- locally advanced or metastatic breast cancer who had received no prior systemic treatment for their advanced disease.2
† FACT-B is a 37-item self-reporting instrument containing the 27-question FACT-G survey and a 10-question breast cancer additional concerns scale. A higher score in any FACT-B assessment indicates better QoL. TTD for FACT-B was defined as the duration between baseline and first occurrence of a decrease of ≥7 points in FACT-B score with no subsequent observation of a <7-point decrease1
§ PRO analyses were based on the PRO-evaluable population (i.e., patients in the intent-to-treat [ITT] population with a baseline and >=1 post-baseline assessment before the end of study treatment)
IBRANCE® + Aromatase Inhibitor (AI) Clinical Trial Results
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IBRANCE® safety information and outcomes
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PP-PFE-GBR-3863. November 2021
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