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Pfizer MedicinesTherapy AreasExplore ContentEventsVideosMaterialsFeatured ArticlesLet’s ConnectSupplyAlliance HealthcareOff-contract claims

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DosingDosingIBRANCE® Dosing
 
Monitoring Requirements
SafetySafetyIBRANCE® Safety ProfileNeutropeniaAdverse Event ManagementClinical Trials
Clinical TrialsIBRANCE® Clinical TrialsIBRANCE® PALOMA-2 Trial
 
IBRANCE® PALOMA-3 Trial
Real World EvidenceReal World EvidenceIBRANCE® Real World EvidenceIRIS (UK) StudyROIS
 
P-REALITY X
Patient ProfilesThe Ibrance® PatientPatient ProfilesAlison - >65 years with comorbiditiesBecky - Postmenopausal with bone-only diseaseSupport and ResourcesSupport and ResourcesIBRANCE Service SupportMaterials
 
Videos

The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain and Northern Ireland. IBRANCE® (palbociclib) Prescribing Information for Great Britain and Northern Ireland click here.  Adverse event reporting information can be found at the bottom of the page.

IBRANCE® (palbociclib) is indicated for the treatment of HR+ HER2- locally advanced or metastatic breast cancer in combination with an AI, or in combination with fulvestrant in women who have received prior endocrine therapy. In pre- or perimenopausal women, the endocrine therapy should be combined with a LHRH agonist.1
PALOMA-3 Trial

Confidence in a Treatment that’s setting the standard2-4

IBRANCE® (palbociclib) + Fulvestrant

Primary results from a Phase III trial of IBRANCE® plus fulvestrant compared with fulvestrant alone in women with HR+/HER2- locally advanced and metastatic breast cancer that progressed on previous endocrine therapy.2-4

Study Design

Study design and patient populations for the Phase III PALOMA-3 Trial

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Efficacy Outcomes

Efficacy outcomes including mPFS, mOS and the impact of prior chemotherapy on IBRANCE® efficacy

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Quality of Life Outcomes

EORTC QLQ-C30 Quality of Life outcomes

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Safety Profile

IBRANCE® Safety Profile and frequently reported adverse events

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Real World Evidence

Real-world patient data for IBRANCE® in advanced breast cancer

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AI : Aromatase Inhibitor, EORTC QLQ-C30 : European Organisation for Research and Treatment of Cancer Quality Of Life Questionnaire C30,  ET : endocrine therapy, HR+/ HER2- : Hormone Receptor‑Positive/ Human Epidermal Growth Factor Receptor 2-Negative, LHRH : Luteinising Hormone-Releasing Hormone, mOS : Median Overall Survival, mPFS : Median Progression-Free Survival, SmPC : Summary Of Product Characteristics.

References

IBRANCE® Summary of Product Characteristics for Great Britain click here. IBRANCE® Summary of Product Characteristics for Northern Ireland click here.Cristofanilli M, et al. Lancet Oncol 2016;17:425–439.Cristofanilli M, et al. ECJ 2018;104:21-31. Turner NC, et al. N Engl J Med 2018;379:1926–1936 including supplementary appendix.
PP-IBR-GBR-5603. January 2024

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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