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The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain and Northern Ireland. IBRANCE® (palbociclib) Prescribing Information for Great Britain and Northern Ireland click here.  Adverse event reporting information can be found at the bottom of the page.

Dosing 

Confidence Through Simplicity1

IBRANCE® has a convenient, once daily, oral regimen.

​​​​​​​The recommended starting dose is 125 mg of IBRANCE® once daily for 21 consecutive days followed by 7 days off treatment (schedule 3/1) to comprise a complete cycle of 28 days.1

Treatment with IBRANCE® should be continued as long as the patient is deriving clinical benefit from therapy or until unacceptable toxicity occurs.1

IBRANCE® 4 Week Dosing Schedule


​​​​​​​How to take IBRANCE®

IBRANCE® can be taken with or without food. No additional dose should be taken if a dose is missed, and the next prescribed dose should be taken at the usual time. IBRANCE® should be swallowed whole, not chewed, crushed or opened prior to swallowing.1

Available Doses 

IBRANCE® is available in 3 dose levels to facilitate dose modification.1

IBRANCE® Dose Levels


​​​​​​​It is important for patients to start on the 125 mg daily dose as the majority of patients treated with IBRANCE® do not require a dose reduction.2,3

In the PALOMA Clinical Trial Programme ≥1 dose reduction due to adverse events were recorded in 36% of IBRANCE®-treated patients in PALOMA-2 and in 34% in PALOMA-3.2,3

​​​​​​​If further dose reduction below 75 mg/day is required, discontinue IBRANCE®.​​​​​​​1

As with all medications, IBRANCE® may interact with certain drugs. Please refer to the IBRANCE® Summary of Product Characteristics for a complete list of drug-drug interactions.


References
  1. IBRANCE® Summary of Product Characteristics for Great Britain click here. IBRANCE® Summary of Product Characteristics for Northern Ireland click here.
  2. Cristofanilli M, et al. Lancet Oncol. 2016;17(4):425-439.
  3. Finn RS, et al. N Engl J Med. 2016;375:1925-36. Supplementary appendix.
PP-IBR-GBR-4236. February 2022

Dosing

Dosing and Monitoring requirements for IBRANCE®

  • Monitoring Requirements

Clinical Trials

  • Clinical Trial results for IBRANCE®
  • IBRANCE® Clinical Trials
  • PALOMA-2 Trial

    ​​​​​​​PALOMA-3 Trial

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Safety

IBRANCE® safety information and outcomes
  • IBRANCE® Safety Profile
  • Neutropenia
  • Adverse Event Management

Indication

  • IBRANCE® is indicated for the treatment of HR+/HER2- locally advanced or metastatic breast cancer:
       - In combination with an aromatase inhibitor; or
    ​​​​​​​   - In combination with fulvestrant in women who have received prior ET

    In pre- or perimenopausal women, the ET should be combined with a LHRH agonist

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PP-PFE-GBR-3863. November 2021

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