The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain. IBRANCE® (palbociclib) Prescribing Information for Great Britain click here. IBRANCE® (palbociclib) Prescribing Information for Northern Ireland click here. Adverse event reporting information can be found at the bottom of the page.
Confidence Through Simplicity1
IBRANCE® has a convenient, once daily, oral regimen.
The recommended starting dose is 125 mg of IBRANCE® once daily for 21 consecutive days followed by 7 days off treatment (schedule 3/1) to comprise a complete cycle of 28 days.1
Treatment with IBRANCE® should be continued as long as the patient is deriving clinical benefit from therapy or until unacceptable toxicity occurs.1
IBRANCE® can be taken with or without food. No additional dose should be taken if a dose is missed, and the next prescribed dose should be taken at the usual time. IBRANCE® should be swallowed whole, not chewed, crushed or opened prior to swallowing.1
IBRANCE® is available in 3 dose levels to facilitate dose modification.1
It is important for patients to start on the 125 mg daily dose as the majority of patients treated with IBRANCE® do not require a dose reduction.2,3
In the PALOMA Clinical Trial Programme ≥1 dose reduction due to adverse events were recorded in 36% of IBRANCE®-treated patients in PALOMA-2 and in 34% in PALOMA-3.2,3
If further dose reduction below 75 mg/day is required, discontinue IBRANCE®.1
As with all medications, IBRANCE® may interact with certain drugs. Please refer to the IBRANCE® Summary of Product Characteristics for a complete list of drug-drug interactions.
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.
Dosing and Monitoring requirements for IBRANCE®
Efficacy results for IBRANCE®
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PP-PFE-GBR-2688. December 2020