The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain. IBRANCE® (palbociclib) Prescribing Information for Great Britain click here. IBRANCE® (palbociclib) Prescribing Information for Northern Ireland click here. Adverse event reporting information can be found at the bottom of the page.
Confidence in a Treatment that's Setting the Standard1-2
The growth of HR+ breast cancer is dependent on cyclin D1, a direct transcriptional target of the ER3-4
a. Cyclin D1 activates CDK4/6 resulting in G1–S phase transition and entry into the cell cycle3-4
b. Cell-line models of endocrine resistance remain dependent on cyclin D1 and CDK4/63-4
IBRANCE® is an orally active selective inhibitor of CDK4 and CDK6 kinases.5-6
IBRANCE® blocks Rb phosphorylation at concentrations of 9–15 nmol/l, inducing G1 arrest in Rb+ tumour cell lines.5
Synergy between ER and CDK4/6 has led to IBRANCE® being developed in combination with endocrine therapy as treatment for HR+/HER2- mBC.6
Adapted from Cadoo KA, et al. Breast Cancer Targets and Therapy. 2004;6:123–33.2
ER : Oestrogen Receptor, HR+ : Hormone Receptor Positive, HER2- : Human Epidermal growth factor Receptor 2-negative, mBC : metastatic Breast Cancer
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.
IBRANCE® + Aromatase Inhibitor (AI) Clinical Trial Results
Efficacy results for IBRANCE®
IBRANCE® safety information and outcomes
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PP-PFE-GBR-2688. December 2020