The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain. IBRANCE® (palbociclib) Prescribing Information for Great Britain click here. IBRANCE® (palbociclib) Prescribing Information for Northern Ireland click here. Adverse event reporting information can be found at the bottom of the page.
Confidence In A Treatment You Can Manage1-6
Neutropenia (any grade) was the most frequently reported Adverse Event (AE) for IBRANCE®▼ (palbociclib) in combination with Endocrine Therapy (ET):
across the Phase III IBRANCE® Clinical Trial Programme.1
Adapted from Verma S, et al. Oncologist. 2016;21:1165-752
* In a population of pre-/peri- and post-menopausal women with HR+/HER2- locally advanced breast cancer with relapse or progression on or after ET in the adjuvant setting, randomised to receive IBRANCE® + fulvestrant or placebo + fulvestrant. Data from all randomly assigned patients who received at least one dose of IBRANCE® plus fulvestrant.2
In clinical studies and clinical practice, most cases of Grade ≥3 Neutropenia occurred during the first two cycles of treatment.2,7
Due to its mechanism of action, IBRANCE®-induced Neutropenia differs from that seen with Chemotherapy.2,8,9
Whilst IBRANCE® suppresses the bone marrow by inducing cell cycle arrest, Chemotherapy causes cellular death, including bone marrow cells.8,9
The 3:1 IBRANCE® Dosing Schedule provides a 1-week Recovery Period that allows arrested bone marrow cells to resume their function, while tumour cell growth remains suppressed by the concomitant ET partner.1,9
AE : Adverse Event, ET : Endocrine Therapy, HR+/HER2– : Hormone Receptor Positive / Human Epidermal Growth Factor Receptor 2 Negative
▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 of the SmPC for how to report adverse reactions.
IBRANCE® safety information and outcomes
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PP-PFE-GBR-2688. December 2020