This site contains promotional information intended only for healthcare professionals resident in the United Kingdom
Menu
Close
Example of description text sitting alongside header
Example of description text sitting alongside header
Menu
Close
Example of description text sitting alongside header
Example of description text sitting alongside header
Menu
Close
Adverse event reporting can be found at the bottom of the page
Menu
Close
The content of this website has been produced in line with the IBRANCE® Summary of Product Characteristics for Great Britain and Northern Ireland. IBRANCE® (palbociclib) Prescribing Information for Great Britain and Northern Ireland click here. Adverse event reporting information can be found at the bottom of the page.
Confidence In A Treatment You Can Manage1-6
Neutropenia (any grade) was the most frequently reported Adverse Event (AE) for IBRANCE® (palbociclib) in combination with Endocrine Therapy (ET):
across the Phase III IBRANCE® Clinical Trial Programme.1
Adapted from Verma S, et al. Oncologist. 2016;21:1165-752
* In a population of pre-/peri- and post-menopausal women with HR+/HER2- locally advanced breast cancer with relapse or progression on or after ET in the adjuvant setting, randomised to receive IBRANCE® + fulvestrant or placebo + fulvestrant. Data from all randomly assigned patients who received at least one dose of IBRANCE® plus fulvestrant.2
In clinical studies and clinical practice, most cases of Grade ≥3 Neutropenia occurred during the first two cycles of treatment.2,7
Due to its mechanism of action, IBRANCE®-induced Neutropenia differs from that seen with Chemotherapy.2,8,9
Whilst IBRANCE® suppresses the bone marrow by inducing cell cycle arrest, Chemotherapy causes cellular death, including bone marrow cells.8,9
The 3:1 IBRANCE® Dosing Schedule provides a 1-week Recovery Period that allows arrested bone marrow cells to resume their function, while tumour cell growth remains suppressed by the concomitant ET partner.1,9
AE : Adverse Event, ET : Endocrine Therapy, HR+/HER2– : Hormone Receptor Positive / Human Epidermal Growth Factor Receptor 2 Negative
References
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search
for MHRA Yellow Card in Google Play or Apple App Store
Adverse events should also be reported to Pfizer Medical Information on 01304 616161
To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.
This site is intended only for healthcare professionals resident in the United Kingdom. If you are a member of the public wishing to access information on a specific medicine, please visit www.medicines.org.uk/emc
This website is brought to you by Pfizer Limited, a company registered in England
and Wales under No. 526209 with its registered office at Ramsgate Road, Sandwich, Kent, CT13 9NJ
Copyright © 2023 Pfizer Limited. All rights reserved.
VAT registration number GB201048427
These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
I confirm that I am a healthcare professional* resident in the United Kingdom.
If you select 'No', you will be redirected to Pfizer.co.uk where you will be able to access reference information on Pfizer's prescription medicines.
*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.
PP-PFE-GBR-3863. November 2021