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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Click here for Inflectra® (infliximab) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

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Optimising treatment (TDM)

Optimising treatment (Biomarkers)

Therapeutic Drug Monitoring (TDM) and biomarkers such as faecal calprotection (FC) can be useful tools in helping to support clinical decision making to optimsie treatment. Treatment optimisation can involve changing the dosing, infusion interval or stopping treatment. 

Please note that Inflectra/infliximab is not licensed for dose escalation in ulcerative colitis, ankylosing spondylitis, psoriasis, psoriatic arthritis, paediatric ulcerative colitis or paediatric Crohn's disease.

What is Faecal Calprotectin?

Faecal calprotectin (FC) is a biomarker of disease activity in IBD.

FC correlates with inflammatory activity in CD and UC.1 

It is stable in stool for up to 3 days at room temperature so it is readily mesaurable.2 

FC levels can be used to:

  • Confirm active disease (when clinical symptoms are present)3
  • Evaluate efficacy of current thearpy (mucosal healing)4
  • Predict disease course5
  • Stratify treatment (modulating disease course)6

Listen to KOLs discuss the use of biomarkers in IBD:

Mechanism of action

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References
  1. Røseth AG, et al. Scand J Gastroenterol 1999. 34:50–54.
  2. Lasson A, et al. J Crohns Colitis 2015. 9:26–32.
  3. Lin JF, et al. Inflamm Bowel Dis 2014. 20:1407–1415.
  4. Røseth AG, et al. Scand J Gastroenterol 2004. 39:1017–1020.
  5. Lewis JD. Gastroenterology 2011. 140:1817–1826.
  6. Osterman MT, et al. Clin Gastroenterol Hepatol 2014. 12:1887–1893.
PP-IFA-GBR-0443. March 2021

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PP-PFE-GBR-2688. December 2020

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