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Adverse event reporting can be found at the bottom of the page
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The content of this website has been produced in line with the INLYTA® (axitinib) Summary of Product Characteristics for Great Britain.
Prescribing Information for INLYTA® (axitinib) click here. Prescribing Information for SUTENT® (sunitinib malate) click here. Adverse event reporting information can be found at the bottom of the page.
INLYTA® is an inhibitor of multiple receptor tyrosine kinases (TKIs), including vascular endothelial growth factor receptors (VEGFR) required for angiogenesis.1 Dysregulation of the VEGF pathway is frequently associated with RCC, due to loss of function of the von Hippel-Lindau gene2, making mRCC a highly vascular tumour, and underlying why the VEGF pathway continues to be a target in RCC.2
'Half-life' is an estimate of the time that it takes for the amount of medicine in the body (usually measured as blood concentration) to be reduced by half
The short half-life of INLYTA® ensures that it is cleared more quickly following dose interruptions/discontinuations3,4
INLYTA® | 2.5-6.1 hours |
Sorafenib | ~ 25-48 hours |
Lenvantinib | ~ 28 hours |
Everolimus | ~ 30 hours |
Cabozantinib | ~ 110 hours |
Tivozanib | 108-122.4 hours |
Sunitinib | 40-60 hours (Sunitinib) and 80-110 hours (active metabolite of Sunitinib) |
Pazopanib | 30.9 hours |
Nivolumab | 25 days |
A short half-life means that AEs have the potential to be resolved quickly after treatment interruption4
A randomised, multicentre, Phase III trial in 723 patients with mRCC with disease progression on first-line therapy (sunitinib or cytokine), comparing the efficacy and safety of INLYTA® 5mg twice daily and sorafenib 400 mg twice daily.
In a phase III clinical trial, INLYTA® demonstrated superior efficacy over sorafenib as second-line therapy2,3
Kaplan-Meler curve of progression-free survival assessed by blinded independent radiology review committee for the overal ITT population (adapted from INLYTA® Summary of Product Characteristics)2,3
ORR in the overall ITT population assessed by blinded independent radiology review committee (adapted from INLYTA® Summary of Product Characteristics)2,3
RCC : Renal Cell Carcinoma, aRCC : advanced Renal Cell Carcinoma
References
INLYTA® is indicated for the treatment of adult patients with advanced renal cell carcinoma (aRCC) after failure of prior treatment with sunitinib or a cytokine1
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search
for MHRA Yellow Card in Google Play or Apple App Store
Adverse events should also be reported to Pfizer Medical Information on 01304 616161
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PP-PFE-GBR-3863. November 2021