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AboutAlopecia AreataBurden of Alopecia AreataMOAEfficacySafety ProfileOverviewSALT score ≤10SALT score ≤20PGI-CEyebrow and Eyelash ResponsesBefore and After Patient ImagesSafety ProfileSafety ProfileContraindications, Special Warnings and PrecautionsAdverse ReactionsPatient ProfilesGetting Started
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Click here for ▼LITFULO (ritlecitinib) Prescribing Information

Overview

SALT score ≤20

Eyebrow and Eyelash Responses

Before and After Patient images

SECONDARY OUTCOME: Proportion of patients who achieved SALT score ≤20 at Week 24 vs placebo1

With Litfulo (ritlecitnib), significantly more patients achieved SALT score ≤20 versus placebo at Week 241,2

At Week 24, significantly more patients treated with Litfulo 50mg once a day achieved response based on SALT score ≤ 20 versus placebo; estimated response rate 23% (n=29) vs 1.6% (n=2) respectively (difference between groups was 21.4% [95% CI:13.4-29.5]: p<0.000001)1,2 Adapted from Litfulo SPC1 and Data on File.2Placebo (N=131); Placebo groups from the study were combined for analysis. n=participants with SALT score ≤20 response (before imputation); N=N1+N2+N3, N=total number of participants in the full analysis set categorised under: N1= participants with non-missing SALT score; N2= participants with missing SALT score due to COVID-19 assumed to be MAR; N3= participants with missing SALT score due to reasons unrelated to COVID-19 considered as non-responders.

Data limitation:
Multiple imputation methods were based on generalised linear mixed model for longitudinal binary data up to Week 24, with an assumption of missing at random (MAR) for SALT scores missing at Week 24 due to COVID-19. Patients with SALT scores missing at Week 24 due to other reasons were included in the analysis as nonresponders. A single complete imputed data set for Week 24 was analysed using the Miettinen and Nurminen method2

SECONDARY OUTCOME: Proportion of patients with SALT score ≤20 to Week 484

Extension period: Increased scalp hair response (SALT score ≤20) was observed to Week 48 (not placebo-controlled)1,3,4

Up to Week 48 of the extension period, an increase in the proportion of patients on Litfulo 50mg once a day with SALT score ≤20 response was observed (43.2% [54/125]; 95% CI: 34.5-51.9; not placebo-controlled period).1–3 N: Number of participants in the full analysis set population. n/N1(%): Number of participants with SALT score ≤10 (percentage based on N1) / Number of participants with valid data at the analysis visit (Non-response for missing due to reasons unrelated to COVID-19; excludes missing due to COVID-19).5

Data limitations:
Cases with missing data at that timepoint due to COVID-related reasons are excluded from n and N1. Cases with missing data at that timepoint due to reasons unrelated to COVID-19 are considered as non-response3 SALT Evaluation >>LoadingSALT Example >>    Loading
Patient reported outcomes (PGI-C)
SALT score ≤20 = Severity of Alopecia Tool score of ≤20 (80% or more scalp hair coverage). 
SALT scores range from 0 to 100 with 0 = no scalp hair loss and 100 = total scalp hair loss.1 
*CI is calculated based on normal approximation.

CI=confidence interval; COVID=coronavirus disease; MAR=missing at random; SALT=Severity of Alopecia Tool; SPC=summary of product characteristics.
References

1. Litfulo (ritlecitinib) Summary of Product Characteristics
2. Pfizer Ltd. Data on File: REF-LGF0041. Litfulo (ritlecitinib) scalp hair response based on SALT score ≤20 at Week 24
3. Pfizer Ltd. Data on File: REF-LGF0042. Litfulo (ritlecitinib) scalp hair response based on SALT score ≤20 at Week 48 
4. King B, Zhang X, Harcha WG, et al. Lancet. 2023. May 6;401(10387):1518-1529, supplementary
PP-LGF-GBR-0312. July 2025

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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