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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Prescribing Information for NGENLA▼(somatrogon) can be found here. Prescribing Information for Genotropin (somatropin) can be found here. Adverse event reporting information can be found at the bottom of the page.

What is NGENLA?

NGENLA is indicated for the treatment of children and adolescents from 3 years of age with growth disturbance due to insufficient secretion of growth hormone (GH). NGENLA is a long-acting GH with once-weekly dosing and may deliver a preferred treatment experience vs daily Genotropin. NGENLA is available with Pfizer-funded patient support and has a comparable cost to other daily GH options.​​​​​​​1,2,3

Pfizer has been dedicated to supporting children with GH disorders, including paediatric GH deficiency, to achieve their growth potential for over 30 years.4

NGENLA administered once-weekly demonstrated significant reduction in treatment burden, greater patient convenience, greater intent to comply and greater patient preference compared with daily Genotropin (somatropin).​​​​​​​1,2

Pfizer can support you in initiating your patients on NGENLA, whilst patients and caregivers can have peace of mind that they can continue to access Pfizer’s patient support programme.
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Mode of Action

Once-weekly dosing with NGENLA is achieved with C-Terminal Peptide (CTP) technology, extending the half-life of human Growth Hormone (hGH).

Somatrogon is composed of a human Growth Hormone molecule fused with C-terminal peptide (CTP) from naturally occurring human chorionic gonadotropin (hCG).1,5

• C-terminal peptides are naturally occurring peptides derived from the beta chain of hCG.5

• C-terminal peptides provide hCG with required longevity, but do not impact interaction with hCG and its receptor.5

• Like hGH, somatrogon binds to the GH receptor and initiates a cascade leading to changes in growth and metabolism.1

References: 
​​​​​​​
1. ​​NGENLA Summary of Product Characteristics for Great Britain: https://www.medicines.org.uk/emc/search?q=ngenla & Northern Ireland: https://www.emcmedicines.com/en-gb/northernireland/medicine?id=4319e9d0-5396-4363-8dcb-bc72051b39da&type=smpc

2. Maniatis AK, Carakushansky M, Galcheva S, et al. Perception of treatment burden with once weekly Somatrogon vs once daily Genotropin in pediatric patients with growth hormone deficiency: results from a randomized phase 3 study. Poster 6895 presented at: Annual Meeting of the Endocrine Society [virtual]; March 20-23, 2021.
3. BNF database (somatropin). Accessed via Medicines Complete. https://about.medicinescomplete.com/. Accessed May 2022.
4. Ranke MB, Price DA, Reiter EO (eds): Growth Hormone Therapy in Pediatrics - 20 Years of KIGS. Basel, Karger, 2007, pp 1-5. doi:10.1159/000101492
​​​​​​​5. Calo D, Hart G, Hoffman M, et al. Enhancing the longevity and in vivo potency of therapeutic proteins: the power of CTP. Precis Med. 2015;2:e989. doi:10.14800/pm.98

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Access practical support for initiating patients on NGENLA and learn more about patient preference for weekly dosing.

Initiating NGENLA

Access data on the efficacy and safety profile of NGENLA.

Efficacy and Safety

PP-NGE-GBR-0034. May 2022

For UK Healthcare Professionals*

These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.

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If you select 'No', you will be redirected to Pfizer.co.uk where you will be able to access reference information on Pfizer's prescription medicines.

*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.

PP-PFE-GBR-3863. November 2021

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