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Click here for Nimenrix® (meningococcal groups A, C, W-135 and Y conjugate vaccine) Prescribing Information.  Adverse event reporting information can be found at the bottom of the page.

Nimenrix Dosing and Administration

Nimenrix (meningococcal groups A, C, W-135 and Y conjugate vaccine) is indicated for active immunisation of individuals from the age of 6 weeks against invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W-135 and Y.1

Nimenrix dosing schedule:*,†,1

Recipient Age

Primary Immunisation Schedule

Infants from 6 weeks to less than 6 months of age

Two doses:
1st dose (0.5ml) given from 6 weeks of age
2nd dose (0.5ml) given 2 months after 1st dose

Infants from 6 months of age, children, adolescents and adults

Single (0.5ml) dose

Booster Dose:1

After completion of the primary immunisation course in infants 6 weeks to less than 12 months of age, a booster dose should be given at 12 months of age with an interval of at least 2 months after the last Nimenrix vaccination.

In previously vaccinated individuals 12 months of age and older, Nimenrix may be given as a booster dose if they have received primary vaccination with a conjugated or plain polysaccharide meningococcal vaccine.

Method of administration:1

  • Immunisation should be carried out by intramuscular injection only
  • The recommended injection site is the anterolateral aspect of the thigh in infants. The anterolateral aspect of the thigh or deltoid muscle is the recommended injection site for individuals from 1 year of age

*See prescribing information for further information

†Nimenrix should be used in accordance with official recommendations

Nimenrix Reconstitution and Administration

Nimenrix is available as a single pack with two needles for reconstitution and administration (23G blue and 25G orange, 25mm).2 Nimenrix is supplied as powder in a vial and solvent in a pre-filled syringe. The vaccine is reconstituted with the solvent presented in the pre-filled syringe.  These components require reconstitution prior to administration.1

How is Nimenrix reconstituted?1​​​​​​​

1

In one hand, hold the syringe barrel (avoid holding the syringe plunger) and unscrew the syringe cap by twisting it anti-clockwise.

2

Attach the needle to the syringe by twisting it clockwise into the syringe until it locks, then remove the needle protector.

3

Inject the solvent from the syringe into the vial containing powder to reconstitute the vaccine components.

4

After all the solvent has been injected into the vial, shake well to ensure all the powder has dissolved.

How is Nimenrix administered?1

1

Once reconstituted, inspect the solution. Nimenrix should appear as a clear, colourless solution. If any foreign particulate matter is visible or there is a variation in the physical appearance, the vaccine should be discarded.

2

Using a new needle, administer 0.5 ml of reconstituted Nimenrix as a single intramuscular injection.

3

Dispose of any unused product or waste material in accordance with local requirements.

Visuals sourced and adapted from www.vecteezy.com.​​​​​​​

View and download a Nimenrix reconstitution and administration guide.

Download now

How should Nimenrix be stored?1

Before reconstitution – Nimenrix should be stored in the refrigerator between 2°C and 8°C in its original packaging. It has a shelf life of 4 years, but the expiry date on the packaging should always be checked prior to use.

After reconstitution – Nimenrix should be used promptly following reconstitution. Although delay is not recommended, stability has been demonstrated for 8 hours at 30°C after reconstitution. If the vaccine is not used within 8 hours, it should not be administered.


References
  1. Nimenrix. Summary of Product Characteristics, United Kingdom, Pfizer Ltd. Available here
  2. Pfizer data on file, February 2020.
PP-NIM-GBR-0247. March 2021

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