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About Oxbryta®Reimbursement InformationReimbursement InformationNICE Guidance SMC Guidance Clinical Trial DataSafety ProfileDosing Experience with Oxbryta Supporting ResourcesSupporting ResourcesContact UsVideosDownloadable resourcesFormulary Pack

Click here for Oxbryta®▼ (voxelotor) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

About Oxbryta®Indication

Oxbryta® (voxelotor) is indicated for the treatment of haemolytic anaemia due to sickle cell disease (SCD) in adults and paediatric patients 12 years of age and older as monotherapy or in combination with hydroxycarbamide.1

SCD is associated with substantial disease burden
  • Sickle cell disease affects an estimated 15,000 people in the UK2
  • Sickle cell disease is characterised by progressive and cumulative organ damage, and a shortened life expectancy (estimated median 67 years in the UK)3–6
Haemoglobin S (HbS) polymerisation is the molecular basis of SCD
  • HbS polymerisation causes red blood cell (RBC) sickling and haemolytic anaemia;4,7–9 released components of haemolysed RBCs contribute to vasomotor dysfunction and vasculopathy, among other events8
  • Haemolytic anaemia – along with vasculopathy and other features of the pathophysiology – contributes to sickle cell disease complications3,8

Oxbryta® targets HbS polymerisation, which could reduce morbidity and mortality in sickle cell disease

  • By inhibiting HbS polymerisation, Oxbryta® offers the potential to reduce haemolytic anaemia and its downstream effects1,7
Dosing and administration

What you need to know about Oxbryta® in clinical practice

 DosingLoading Clinical trial data

Discover the efficacy and safety profile of Oxbryta® from the HOPE clinical trial

DataLoadingKickerReferences:1. Oxbryta® (voxelotor) Summary of Product Characteristics.
2. Sickle Cell Society. About sickle cell. Available at https://www.sicklecellsociety.org/about-sickle-cell/. Accessed July 2023.
3. Ataga KI, et al. PLoS One. 2020;15(4):e0229959.
4. Kato GJ, et al. Nat Rev Dis Primers. 2018;4:18010.
5. Oguanobi NI, et al. ISRN Hematol. 2012;2012:768718.
6. NICE. Clinical knowledge summary: Sickle cell disease. Available at https://cks.nice.org.uk/topics/sickle-cell-disease/background-information/prognosis/. Accessed July 2023
7. Vichinsky E, et al. N Engl J Med. 2019;381(6):509–519.
8. Kato GJ, et al. J Clin Invest. 2017;127(3):750–760.
9. AlDallal SM, et al. Cureus. 2020;12(2):e7105.
PP-LTV-GBR-0420. June 2024

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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