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Mechanism of Action DosingDosing InformationDose AdjustmentsDrug Interactions Trial Design & EfficacyTrial DesignEfficacySafety Profile & Tolerability  Support & ResourcesFrequently Asked QuestionsEducational ResourcesHCP Experience VideosNICE Guidance

Prescribing Information for PAXLOVID (nirmatrelvir / ritonavir) can be found here: Great Britain and Northern Ireland

Adverse event reporting information can be found at the bottom of the page. Please note, there are differences between the SmPC for Northern Ireland and the SmPC for Great Britain. Please refer to the appropriate SmPC depending on where you are based.

You could treat COVID-19 from patients' homesKicker PAXLOVID (nirmatrelvir/ritonavir) is indicated for the treatment of COVID-19 in adults who do not require supplemental oxygen and who are at increased risk for progressing to severe COVID-19.1,2

Paxlovid has a Conditional Marketing Authorisation in Great Britain.*

*A Conditional Marketing Authorisation means that further evidence on this medicinal product is awaited. New information on this medicinal product will be reviewed when any relevant information of significance becomes available and at least every year and the product information will be updated as necessary.
 

Explore EPIC-HR Clinical Trial Data
Safety & Tolerability

Learn more about the safety and tolerability profile of PAXLOVID.

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Mechanism of Action

Learn about how PAXLOVID inhibits replication by preventing proteolysis from occurring.

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Dosing Learn about PAXLOVID dosing and potential drug interactions before you prescribe.
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Paxlovid is indicated for the treatment of COVID-19 in adults who do not require supplemental oxygen and who are at increased risk for progression to severe COVID-191,2Key factors that put a patient at high risk for progression to severe COVID-19 include3,4,5,6
  • Patients with Down's Syndrome and other chromosomal disorders known to affect immune competence
  • Solid cancers
  • Solid organ transplant recipients
  • Haematological diseases or HSCT recipients
  • Immune-mediated inflammatory disorders
  • Immune deficiencies 
  • Renal disease
    • Paxlovid is contraindicated in patients with severe renal impairment (GB)1
    • Paxlovid should not be used in patients with severe renal impairment [eGFR < 30 mL/min, including patients with End Stage Renal Disease (ESRD) under haemodialysis] (NI)2
  • Liver disease
    • Paxlovid is contraindicated in patients with severe hepatic impairment (Child-Pugh Class C) (GB)1
    • Paxlovid should not be used in patients with severe hepatic impairment (Child-Pugh Class C) (NI)2
  • Rare neurological and severe complex life-limiting neurodisability conditions
  • HIV / AIDS 
  • Respiratory conditions
  • Neurological disorders

Click here to explore more on the highest risk patients as defined by The Independent Advisory Group Report. 
Educational Resources

Explore Paxlovid resources available to support both you and your patients.

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How PAXLOVID Works


PAXLOVID contains nirmatrelvir, a protease inhibitor specifically designed by Pfizer to target the main SARS-CoV-2 protease and inhibit replication by preventing proteolysis from occurring.1,2

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Frequently Asked Questions


Find answers to frequently asked questions on topics that include dosing and potential drug interactions.  

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Footnotes:
AIDS; Acquired immunodeficiency syndrome EPIC-HR; Evaluation of Protease Inhibition for COVID-19 in High Risk Patients, HIV; Human Immunodeficiency Virus

References:
1.
PAXLOVID GB Summary of Product Characteristics. Pfizer Inc.
2. PAXLOVID NI Summary of Product Characteristics. Pfizer Inc.
3. Coronavirus (COVID-19) - NHS: https://www.nhs.uk/conditions/coronavirus-covid-19/self-care-and-treatments-for-coronavirus/treatments-for-coronavirus Last Accessed July 2023 
4. Defining the highest-risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (nMABs) and antiviral drugs: independent advisory group report. Defining the highest risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (nMABs) and antiviral drugs (updated March 2023) - GOV.UK (www.gov.uk) Last Accessed July 2023
5. Treatments for coronavirus (COVID-19) https://www.nidirect.gov.uk/articles/treatments-coronavirus-covid-19 
6. COVID-19 Community Treatments Northern Ireland (NI) - Frequently Asked Questions. Last updated 5th December 2022 https://www.health-ni.gov.uk/sites/default/files/publications/health/doh-covid-19-community-treatments-ni-faqs.pdf
PP-C1D-GBR-0062. November 2023

Adverse Events
 

Adverse Events should be reported. Reporting forms and information can be found at https://coronavirus-yellowcard.mhra.gov.uk/ or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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