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Mechanism of Action DosingDosing InformationDose AdjustmentsDrug Interactions Trial Design & EfficacyTrial DesignEfficacySafety Profile & Tolerability  Support & ResourcesFrequently Asked QuestionsEducational ResourcesHCP Experience VideosNICE Guidance

Prescribing Information for ▼PAXLOVID (nirmatrelvir / ritonavir) can be found here: Great Britain and Northern Ireland. 

Adverse event reporting information can be found at the bottom of the page. Please note, there are differences between the SmPC for Northern Ireland and the SmPC for Great Britain. Please refer to the appropriate SmPC depending on where you are based.

You could treat COVID-19 from patients' homesKicker PAXLOVID (nirmatrelvir/ritonavir) is indicated for the treatment of COVID-19 in adults who do not require supplemental oxygen and who are at increased risk for progressing to severe COVID-19.1,2

Paxlovid has a Conditional Marketing Authorisation in Great Britain.*

NICE recently expanded the recommended eligibility criteria for COVID-19 Treatment. Learn more here.

*A Conditional Marketing Authorisation means that further evidence on this medicinal product is awaited. New information on this medicinal product will be reviewed when any relevant information of significance becomes available and at least every year and the product information will be updated as necessary.

 Explore EPIC-HR Clinical Trial Data Safety Profile & Tolerability

Learn more about the safety profile and tolerability of PAXLOVID.

Learn moreLoadingEducational Resources

Access resources and videos to learn more about PAXLOVID.

ResourcesLoadingHCP Experience VideosLoading Dosing Learn about PAXLOVID dosing and potential drug interactions before you prescribe.
 Find out more LoadingHCP Experience VideosLoadingKey factors that can put a patient at high risk for progression to severe COVID-19 include3,4,5,6: 
  • Patients with Down's Syndrome and other chromosomal disorders known to affect immune competence
  • Solid cancers
  • Solid organ transplant recipients
  • Haematological diseases or HSCT recipients
  • Immune-mediated inflammatory disorders
  • Immune deficiencies 
  • Renal disease
    • Paxlovid is contraindicated in patients with severe renal impairment (GB)1
    • Paxlovid should not be used in patients with severe renal impairment [eGFR < 30 mL/min, including patients with End Stage Renal Disease (ESRD) under haemodialysis] (NI)2
  • Liver disease
    • Paxlovid is contraindicated in patients with severe hepatic impairment (Child-Pugh Class C) (GB)1
    • Paxlovid should not be used in patients with severe hepatic impairment (Child-Pugh Class C) (NI)2
  • Rare neurological and severe complex life-limiting neurodisability conditions
  • HIV / AIDS 
  • Respiratory conditions
  • Neurological disorders
Paxlovid SmPC should be consulted before prescribing. The decision to treat and choice of treatment is based on the
individual patient’s eligibility criteria, clinical circumstances and is ultimately at the discretion of the individual prescriber.

Click here to access a one page summary on the highest risk patients as defined by The Independent Advisory Group Report. 

To learn about the NICE Recommendations for COVID-19 treatment, click here.How PAXLOVID Works


PAXLOVID contains nirmatrelvir, a protease inhibitor specifically designed by Pfizer to target the main SARS-CoV-2 protease and inhibit replication by preventing proteolysis from occurring.1,2

 Find out more LoadingFrequently Asked Questions


Find answers to frequently asked questions on topics that include dosing and potential drug interactions.  

 Frequently Asked Questions Loading
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**Links to a third-party-website (outside of Pfizer). Links to external websites are provided as a resource to the viewer. This website is neither owned or controlled by Pfizer Ltd. Pfizer accepts no responsibility for the content or services of the linked site.

Footnotes:
NICE; National Institute for Health and Care Excellence, AIDS; Acquired immunodeficiency syndrome EPIC-HR; Evaluation of Protease Inhibition for COVID-19 in High Risk Patients, HIV; Human Immunodeficiency Virus

References:
1. PAXLOVID GB Summary of Product Characteristics. Pfizer Inc.
2. PAXLOVID NI Summary of Product Characteristics. Pfizer Inc.
3. Coronavirus (COVID-19) - NHS: https://www.nhs.uk/conditions/coronavirus-covid-19/self-care-and-treatments-for-coronavirus/treatments-for-coronavirus** Last Accessed April 2024. 
4. Defining the highest-risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (nMABs) and antiviral drugs: independent advisory group report. Defining the highest risk clinical subgroups upon community infection with SARS-CoV-2 when considering the use of neutralising monoclonal antibodies (nMABs) and antiviral drugs (updated March 2023) - GOV.UK (www.gov.uk)** Last Accessed April 2024.
5. Treatments for coronavirus (COVID-19) https://www.nidirect.gov.uk/articles/treatments-coronavirus-covid-19** Last accessed April 2024.
6. COVID-19 Community Treatments Northern Ireland (NI) - Frequently Asked Questions. Last updated 5th December 2022 https://www.health-ni.gov.uk/sites/default/files/publications/health/doh-covid-19-community-treatments-ni-faqs.pdf**
PP-C1D-GBR-0283. April 2024

Adverse Events
 

Adverse Events should be reported. Reporting forms and information can be found at https://coronavirus-yellowcard.mhra.gov.uk/ or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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