Prescribing Information for ▼PAXLOVID (nirmatrelvir / ritonavir) can be found here. Adverse event reporting information can be found at the bottom of the page.
Paxlovid has a Conditional Marketing Authorisation in the United Kingdom. A Conditional Marketing Authorisation means that further evidence on this medicinal product is awaited. New information on this medicinal product will be reviewed when any relevant information of significance becomes available and at least every year and the product information will be updated as necessary.
Pharmacists are frontline defenders against COVID-19,1,2 especially for patients at increased risk of hospitalisation or death. This resource hub for pharmacists hosts resources to help prepare your pharmacy to support eligible patients at increased risk of progression to severe COVID-19.
Access essential resources to identify and support eligible patients at increased risk for progression to severe COVID-19
This 3-step plan will help you support patients at increased risk of severe COVID-19.
Paxlovid® is indicated for the treatment of COVID-19 in adults who do not require supplemental oxygen and who are at increased risk of progression to severe COVID-19.3
When administered within 5 days of symptom onset, Paxlovid® can potentially reduce risk of progression to severe COVID-19 in eligible high-risk adult patients.3,4†
Order Paxlovid® stock to your pharmacy today to avoid treatment delays.
Commercial stock of Paxlovid® is now available for order through Pfizer, via your Alliance Healthcare account.
† Trial Data
In the final analysis of the Phase 2/3 EPIC-HR trial, the primary endpoint (the proportion of patients with COVID-19-related hospitalisation or death from any cause through Day 28 in the modified intend-to-treat analysis set [all treated participants with onset of symptoms ≤3 days who had at least one post-baseline visit]) was achieved: Paxlovid® (n = 671) demonstrated an ~89% relative risk reduction in hospitalisation or death compared with placebo (n = 647) (absolute risk reduction -6.14% [95% CI −8.21 to −4.07]; P < 0.0001). The key secondary endpoint (the primary comparison analysed similarly among patients whose treatment began within 5 days after the onset of Covid-19 signs and symptoms) was also achieved, as Paxlovid® (n = 977) demonstrated an 86% relative risk reduction in hospitalisation or death compared with placebo (n = 989) (absolute risk reduction -5.64% [95% CI −7.31 to −3.97]; P < 0.0001).4
The safety profile of Paxlovid® is based on data from three Phase 2/3 randomised, placebo-controlled trials in adult participants 18 years of age and older. Across the three studies, 3515 participants received a dose of Paxlovid® and 2585 participants received a dose of placebo. The most common adverse reactions (≥1% incidence in the Paxlovid group and occurring at a greater frequency than in the placebo group) were dysgeusia (5.9% and 0.4%, respectively) and diarrhoea (2.9% and 1.9%, respectively).3 In addition to the above adverse events, the SmPC also reports nausea and headache as common adverse events.3Anaphylaxis, hypersensitivity reactions and serious skin reactions (including toxic epidermal necrolysis and Stevens-Johnson syndrome) have been reported with Paxlovid®. If signs and symptoms of a clinically significant hypersensitivity reaction or anaphylaxis occur, immediately discontinue Paxlovid and initiate appropriate medications and/or supportive care.
Please refer to the Summary of Product Characteristics for the full list of adverse events.
Community pharmacists are eligible to provide COVID-19 LFD tests to eligible high-risk patients for free through the NHS.5,6
Financial compensation is available for community pharmacists.6
Learn more about the NHS LFD Supply Service here*
Patients with risk factors for severe COVID-19 may be hospitalised and can die.10,12 These patients need to take rapid action upon confirmation of a positive diagnostic COVID-19 test.7,8
High-risk conditions¶ include:9,10

COVID-19 is an ongoing burden on healthcare systems.11 Patients with COVID-19 occupied almost 300,000 bed-days in a single year across NHS England.12
Early treatment can potentially reduce the risk of progression to severe COVID-19 compared to no treatment, reducing the risk of hospitalisation and death.4,13
Watch insights videos from KOL discuss importance of managing high-risk patients

Community pharmacists are eligible to provide COVID-19 LFD tests to eligible high-risk patients for free through the NHS LFD Service.5,6
Financial compensation is available for community pharmacists. Each LFD box given to a patient earns the pharmacy £4.10 plus VAT.
Watch Dr Richard Brown sharing his personal experience and learnings after implementing the NHS LFD service in a group of community pharmacies.
Video duration: 1 min, 30 sec.
Upon a positive COVID-19 test, eligible high-risk adult patients can be treated at home for 5-days with Paxlovid®.3
Oral treatment should begin following a positive COVID-19 test within 5 days of symptom onset, even if the symptoms are mild.3
Before making any prescribing decisions please consult the SmPC for full information including dosing and dosing adjustments, contraindications, adverse events, and special populations.
For full details on the clinical profile of Paxlovid®, explore the links below:
The decision to treat and choice of treatment is based on individual patient's eligibility criteria, clinical circumstances and is ultimately at the discretion of the individual prescriber.
Lana Goodwin discusses techniques to effectively communicate with high risk patients, using best practice examples.
Prof David Strain discusses the key aspects needed for an effective COVID-19 treatment service, highlighting important considerations and best practice which others can use to help optimise their own pathways.
Adverse Events
Adverse Events should be reported. Reporting forms and information can be found at https://coronavirus-yellowcard.mhra.gov.uk/ or search
for MHRA Yellow Card in Google Play or Apple App Store
Adverse events should also be reported to Pfizer Medical Information on 01304 616161
To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.
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PP-UNP-GBR-7812. January 2024.