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Mechanism of Action DosingDosing InformationDose AdjustmentsDrug Interactions Trial Design & EfficacyTrial DesignEfficacySafety Profile & Tolerability  Support & ResourcesPharmacy ResourcesHCP Experience VideosNICE Guidance

Prescribing Information for PAXLOVID (nirmatrelvir / ritonavir) can be found here. Adverse event reporting information can be found at the bottom of the page. 

Paxlovid has a Conditional Marketing Authorisation in the United Kingdom. A Conditional Marketing Authorisation means that further evidence on this medicinal product is awaited. New information on this medicinal product will be reviewed when any relevant information of significance becomes available and at least every year and the product information will be updated as necessary.

COVID-19 Resource Hub

Pharmacists are frontline defenders against COVID-19,1,2 especially for patients at increased risk of hospitalisation or death. This resource hub for pharmacists hosts resources to help prepare your pharmacy to support eligible patients at increased risk of progression to severe COVID-19.

Quick Links

Access essential resources to identify and support eligible patients at increased risk for progression to severe COVID-19

NHS LFD Test Supply ServiceStock up on LFDs and find out about financial compensation for pharmacists*LoadingNICE Guidance on High-Risk PatientsSpot patients most at risk of progressing to severe COVID-19*
©NICE [2025] TA878. All rights reserved. Subject to Notice of rights. NICE guidance is prepared for the National Health Service in England. All NICE guidance is subject to regular review and may be updated or withdrawn. NICE accepts no responsibility for the use of its content in this product/ publication.
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Order Paxlovid®Maintain your Paxlovid® stocks to eliminate treatment delays*Loading
3-step action plan for pharmacists

This 3-step plan will help you support patients at increased risk of severe COVID-19.

1. Prepare your pharmacy
2. Identify eligible high-risk patients3. Tell patients to act quickly   
Stock up on Paxlovid®

Paxlovid® is indicated for the treatment of COVID-19 in adults who do not require supplemental oxygen and who are at increased risk of progression to severe COVID-19.3

When administered within 5 days of symptom onset, Paxlovid® can potentially reduce risk of progression to severe COVID-19 in eligible high-risk adult patients.3,4†

Order Paxlovid® stock to your pharmacy today to avoid treatment delays.

Commercial stock of Paxlovid® is now available for order through Pfizer, via your Alliance Healthcare account. 

  • Orders can be placed using PIP code 435-2712 through your PMR system, the Alliance Healthcare website, or by calling Alliance Healthcare directly. Please note that this is a new PIP code effective from 1st May 2025.
  • Paxlovid® is available to order at NHS list price for a pack of 30 tablets. 
  • Delivery: Orders are delivered twice daily by Alliance Healthcare.
  • Contact for Queries: Should you require any further information, in the first instance, please speak to your Alliance Healthcare branch. 
  • Alternatively, contact the Pfizer Sales Order Management and Customer Excellence team on 0345 6088866 or Freephone 0800 032 7907.

The decision to treat and choice of treatment is based on individual patient's eligiblity criteria, clinical circumstances and is ultimately at the discretion of the individual prescriber


† Trial Data
In the final analysis of the Phase 2/3 EPIC-HR trial, the primary endpoint (the proportion of patients with COVID-19-related hospitalisation or death from any cause through Day 28 in the modified intend-to-treat analysis set [all treated participants with onset of symptoms ≤3 days who had at least one post-baseline visit]) was achieved: Paxlovid® (n = 671) demonstrated an ~89% relative risk reduction in hospitalisation or death compared with placebo (n = 647) (absolute risk reduction -6.14% [95% CI −8.21 to −4.07]; P < 0.0001). The key secondary endpoint (the primary comparison analysed similarly among patients whose treatment began within 5 days after the onset of Covid-19 signs and symptoms) was also achieved, as Paxlovid® (n = 977) demonstrated an 86% relative risk reduction in hospitalisation or death compared with placebo (n = 989) (absolute risk reduction -5.64% [95% CI −7.31 to −3.97]; P < 0.0001).
The safety profile of Paxlovid® is based on data from three Phase 2/3 randomised, placebo-controlled trials in adult participants 18 years of age and older. Across the three studies, 3515 participants received a dose of Paxlovid® and 2585 participants received a dose of placebo. The most common adverse reactions (≥1% incidence in the Paxlovid group and occurring at a greater frequency than in the placebo group) were dysgeusia (5.9% and 0.4%, respectively) and diarrhoea (2.9% and 1.9%, respectively).3   In addition to the above adverse events, the SmPC also reports nausea and headache as common adverse events.3Anaphylaxis, hypersensitivity reactions and serious skin reactions (including toxic epidermal necrolysis and Stevens-Johnson syndrome) have been reported with Paxlovid®. If signs and symptoms of a clinically significant hypersensitivity reaction or anaphylaxis occur, immediately discontinue Paxlovid and initiate appropriate medications and/or supportive care. 
Please refer to the Summary of Product Characteristics for the full list of adverse events.

Stock up on LFDs

Community pharmacists are eligible to provide COVID-19 LFD tests to eligible high-risk patients for free through the NHS.5,6

Financial compensation is available for community pharmacists.6


Learn more about the NHS LFD Supply Service here*

Identify high-risk patients

Patients with risk factors for severe COVID-19 may be hospitalised and can die.10,12 These patients need to take rapid action upon confirmation of a positive diagnostic COVID-19 test.7,8

High-risk conditions include:9,10

  • Immune-mediated inflammatory diseases
  • Immune deficiencies
  • HIV/AIDS
  • Solid organ cancer
  • Liver disease
  • Renal disease
  • Down’s syndrome or other genetic disorders
  • Haematological diseases and HSCT recipients
  • Neurological disorders
  • Respiratory conditions
View NICE guidance*

The decision to treat and choice of treatment are based on the individual patient's eligibility criteria, clinical circumstances and treatment SmPCs, and they are ultimately at the discretion of the individual prescriber. Please refer to SmPC before making any prescribing decisions. 

 Conditions are not mutually exclusive. Adapted from Independent Advisory Group Report, 2023.9
‡ Paxlovid® is contraindicated in patients with severe renal or hepatic impairment.3
Explore the burden of COVID-19

COVID-19 is an ongoing burden on healthcare systems.11 Patients with COVID-19 occupied almost 300,000 bed-days in a single year across NHS England.12
Early treatment can potentially reduce the risk of progression to severe COVID-19 compared to no treatment, reducing the risk of hospitalisation and death.4,13


Watch insights videos from KOL discuss importance of managing high-risk patients


§ Based on the following 4-digit code for primary diagnosis: COVID-19 (U07.1)
Financial compensation for pharmacists 

Community pharmacists are eligible to provide COVID-19 LFD tests to eligible high-risk patients for free through the NHS LFD Service.5,6

Financial compensation is available for community pharmacists. Each LFD box given to a patient earns the pharmacy £4.10 plus VAT. 

Dr Richard Brown
FRPharmS, CEO at Community Pharmacy Avon & Wiltshire. Director ar BRR Consulting Ltd and Virtual Outcomes Ltd.

Watch Dr Richard Brown sharing his personal experience and learnings after implementing the NHS LFD service in a group of community pharmacies. 
Video duration: 1 min, 30 sec.

Treatment with Paxlovid®

Upon a positive COVID-19 test, eligible high-risk adult patients can be treated at home for 5-days with Paxlovid®.3

Oral treatment should begin following a positive COVID-19 test within 5 days of symptom onset, even if the symptoms are mild.3

Before making any prescribing decisions please consult the SmPC for full information including dosing and dosing adjustments, contraindications, adverse events, and special populations.

Explore  Paxlovid ®

For full details on the clinical profile of Paxlovid®, explore the links below:

Paxlovid® Efficacy

Paxlovid® Safety Profile

Paxlovid® Dosing

The decision to treat and choice of treatment is based on individual patient's eligibility criteria, clinical circumstances and is ultimately at the discretion of the individual prescriber. 

HCP experience videosImpact of effective patient communication

Lana Goodwin discusses techniques to effectively communicate with high risk patients, using best practice examples.

Access video here »Loading
What makes a good COVID-19 service

Prof David Strain discusses the key aspects needed for an effective COVID-19 treatment service, highlighting important considerations and best practice which others can use to help optimise their own pathways.

Access video here » Loading

AIDS, acquired immune deficiency syndrome; CI, confidence interval; COVID-19, coronavirus disease 2019; HIV, human immunodeficiency virus; HSCT, Hematopoietic stem cell transplant; LFD, lateral flow device; NHS, National Health Service; NICE, National Institute for Health and Care Excellence; SmPC, Summary of Product Characteristics; VAT, value added tax.

*Links to a third-party-website (outside of Pfizer). Links to external websites are provided as a resource to the viewer. This website is neither owned or controlled by Pfizer Ltd. Pfizer accepts no responsibility for the content or services of the linked site.

References
  1. Elbeddini A, et al. J Pharm Policy Pract. 2020;13:36.
  2. NHS. The role of pharmacists in your healthcare. Available at: https://www.nhsgp.net/the-role-of-pharmacists-in-your-healthcare/.* Accessed September 2025.
  3. Paxlovid® Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/13145/.*
  4. Hammond J, et al. Clin Infectious Dis. 2025;80:323 330.
  5. NHS. What is the LFD Tests Supply Service? Available at: https://faq.nhsbsa.nhs.uk/knowledgebase/article/KA-28706/.* Accessed September 2025.
  6. NHS England. NHS Lateral Flow Device (LFD) Tests Supply Service: Advanced Service. Available at: https://www.england.nhs.uk/primary-care/pharmacy/pharmacy-services/nhs-ltd-tests-supply-service?cmp=b7ff796f-f7cf-43f2-9223-f880b519839d&ttype=PA.* Accessed September 2025.
  7. Gao Y-D, et al. Allergy. 2021;76(2):428–455.
  8. NHS. Treatments for COVID-19. Available at: https://www.nhs.uk/conditions/covid-19/treatments-for-covid-19/.* Accessed September 2025.
  9. Department of Health and Social Care. Higher risk patients eligible for COVID-19 treatments: independent advisory group report. Available at: https://www.gov.uk/government/publications/higher-risk-patients-eligible-for-covid-19-treatments-independent-advisory-group-report-march-2023/defining-the-highest-risk-clinical-subgroups-upon-community-infection-with-sars-cov-2-when-considering-the-use-of-neutralising-monoclonal-antibodies.* Accessed September 2025.
  10. ©NICE [2025] TA878: Available at: https://www.nice.org.uk/guidance/ta878/resources/nirmatrelvir-plus-ritonavir-sotrovimab-and-tocilizumab-for-treating-covid19-pdf-82613679870661.* All rights reserved. Subject to Notice of rights. NICE guidance is prepared for the National Health Service in England. All NICE guidance is subject to regular review and may be updated or withdrawn. NICE accepts no responsibility for the use of its content in this product/ publication. Accessed September 2025.
  11. World Health Organization. WHO Policy Brief: COVID-19 surveillance. December 2024. Available at: https:// www.who.int/publications/m/item/who-policy-brief-covid-19-surveillance.* Accessed September 2025.
  12. NHSE Hospital Admitted Patient Care Activity: Diagnosis 2024–25. Available at: https://files.digital.nhs.uk/CC/EA025D/hosp-epis-stat-admi-diag-2024-25-tab.xlsx.* Accessed September 2025.
  13. Colaneri M, et al. Int J Infect Dis. 2024;149:107265.
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for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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