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Adverse event reporting can be found at the bottom of the page

Administration and Storage Choosing ReFacto AFChoosing ReFacto AFChoosing ReFacto AFPersonalised dosing 

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Product InformationProduct InformationLaboratory StandardEfficacy & SafetyAdministration & StorageSupport & ResourcesSupport & ResourcesMaterialsVideosOrdering ReFacto AFContact Us

For ReFacto AF® (moroctocog alfa) Prescribing Information for Great Britain and Northern Ireland click here.
Adverse event reporting information can be found at the bottom of the page.

When to use 

ReFacto AF® (moroctocog alfa) is indicated for the treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency). ReFacto AF® is appropriate for use in adults and children of all ages, including newborns. ReFacto AF® does not contain von Willebrand factor, and hence is not indicated in von Willebrand's disease.1

Individualisation of care matters. ReFacto AF can be used for prophylaxis, on-demand, and/or surgery.1

ProphylaxisFor long-term prophylaxis against bleeding in patients with severe haemophilia A, the usual doses are 20–40 IU of factor VIII per kg body weight at intervals of 2–3 days. In some cases, especially in younger patients, shorter dose intervals or higher doses may be necessary.1 On-demand 

Patients receiving long-term prophylaxis with clotting factor concentrates or other novel therapies can still experience breakthrough bleeding events, typically associated with traumatic injuries.2 These bleeding events may require on-demand treatment with additional haemostatic agents such as Refacto AF®.2

SurgeryCurrent guidance for the perioperative management of people with haemophilia A includes raising factor levels with clotting factor concentrates including FVIII replacement therapy, such as Refacto AF®,to provide adequate coverage for recovery and rehabilitation.3
Pfizer's Journey

With more than 20 years’ experience treating patients with haemophilia A,1 ReFacto AF® is building on Pfizer’s proud heritage in haemophilia care.

Click here to learn more about Pfizer's commitment in Haemophilia care. 

SHLs: Regular dosing for improved peak controlSHLs: Regular dosing for improved peak control
Explore more Laboratory Standard 

Find out more about the use of Laboratory Standards and patient satisfaction with the ReFacto AF FuseNGo device.

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Materials

Access resources and additional information that aim to support you and your patients.

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Ordering ReFacto AF

Contact us for more information on ReFacto AF and download our FAQ for supply and stock related queries.

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References

ReFacto AF® Summary of Product Characteristics. For Great Britain, available here. For Northern Ireland, available here.Mancuso ME, Mahlangu JN, Pipe SW. Lancet. 2021;13:397(10247):630–640.Srivastava A, et al. Haemophilia 2020;26(Suppl 6):1–158.Collins P, et al. The use of enhanced half-life coagulation factor concentrates in routine clinical practice: guidance from UKHCDO. Haemophilia. 2016;22:487–498.
PP-REF-GBR-0356 July 2023

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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