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Click here for ReFacto AF® (moroctocog alfa) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

ReFacto AF can be given as on-demand treatment or as prophylaxis

On-demand treatment1

The calculation of the required dose of factor VIII is based upon the empirical finding that 1 IU of factor VIII per kg body weight raises the plasma factor VIII activity by 2 IU/dl. The required dose is determined using the following formula:

​​​​​​​Number of factor VIII IU required = body weight (kg) x desired VIII increase (% or IU/dl) x 0.5 (IU/kg per IU/dl), where 0.5 IU/kg per IU/dl represents the reciprocal of the recovery generally observed following infusions of factor VIII.

The amount to be administered and the frequency of administration should always be oriented to the clinical effectiveness in the individual case.

​​​​​​​In the case of the following haemorrhagic events, the factor VIII activity should not fall below the given plasma levels (in percentage of normal or in IU/dl) in the corresponding period. The following table can be used to guide dosing in bleeding episodes and surgery:

Degree of haemorrhage / Type of surgical procedure

Factor VIII level required (%) or (IU/dl)

Frequency of doses (hours) / Duration of therapy (days)

Haemorrhage

Early haemarthrosis, muscle bleeding or oral bleeding

20–40

Repeat every 12-24 hours. At least 1 day, until the bleeding episode as indicated by pain is resolved or healing is achieved.

More extensive haemarthrosis, muscle bleeding or haematoma

30–60

Repeat infusion every 12-24 hours for 3–4 days or more until pain and acute disability are resolved.

Life-threatening haemorrhage

60–100

Repeat infusion every 8–24 hours until threat is resolved.

Surgery

Minor surgery including tooth extraction

30–60

Every 24 hours, at least 1 day, until healing is achieved.

Major surgery

80–100
(pre- and post-operative)

Repeat infusion every 8–24 hours until adequate wound healing, then therapy for at least another
7 days to maintain a factor VIII activity of 30% to 60% (IU/dL)

Adapted from ReFacto AF (moroctocog alfa) Summary of Product Characteristics.1

Prophylaxis1

​​​​​​​For long-term prophylaxis against bleeding in patients with severe haemophilia A, the usual doses are 20 to 40 IU of factor VIII per kg body weight at intervals of 2 to 3 days. In some cases, especially in younger patients, shorter dose intervals or higher doses may be necessary.

Explore more

Find out how to order the ReFacto AF Laboratory Standard

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Find out about how ReFacto AF is administered and reconstituted

Click here

IU = international units.
References
  1. ReFacto AF (moroctocog alfa) Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/6558/smpc
PP-REF-GBR-0198. March 2021

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Speak to a member of the Pfizer Haemophilia team.

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Find out about ReFacto AF efficacy 

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