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Click here for ReFacto AF® (moroctocog alfa) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

​​​​​​​Reliable efficacy when you and your patients need it most1,2

​​​​​​​Prophylaxis

Prophylactic treatment in PTPs

Reduction in annual bleed rate (ABR) vs on-demand in previously treated patients (PTPs). ReFacto AF prophylaxis is more effective at preventing bleeds than on-demand treatment, with an 85% reduction of bleeds per year (median ABR: 3.4; n=154) 
achieved with prophylactic treatment3

On-demand treatment

On-demand treatment in PTPs

of 10,882 bleeding episodes were treated effectively with only 1 infusion (n=113)1,2

On-demand treatment in previously untreated patients (PUPs)

of 2,715 bleeding episodes were treated effectively with only 1 infusion (n=101)1,2

Surgery

of infusions administered were rated as excellent or good by the surgeon and treating physician (38 patients; 48 surgical procedures; 496 infusions during or after surgery)1,*

ReFacto AF is manufactured using the same cell line as ReFacto4 and is bioequivalent to ReFacto and pharmacokinetically equivalent to a full-length recombinant factor VIII (FLrFVIII) comparator5, so it is expected to behave in the same way.

​​​​​​​*Excellent rating: achievement of comparable haemostasis to that expected after similar surgery in a non-haemophilic patient. Good rating: prolonged time to haemostasis with somewhat increased bleeding compared with that expected after similar surgery in a non-haemophilic patient.1

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Find out about the safety profile of ReFacto AF. 

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Find out about ReFacto AF dosing for on-demand treatment and prophylaxis

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ABR = annualised bleeding rate;
BU = Bethesda units;
PTP = previously treated patient;
​​​​​​​PUP = previously untreated patient.
References
  1. Lusher JM et al. The safety and efficacy of B-domain deleted recombinant factor VIII concentrate in patients with severe haemophilia. Haemophilia 2003;9:38–49.
  2. Lusher JM and Roth DA. The safety and efficacy of B-domain deleted recombinant factor VIII concentrates in patients with severe haemophilia A: an update. Haemophilia 2005;11:292–293.
  3. Parra Lopez R et al. Prospective surveillance study of haemophilia A patients switching from moroctocog alfa or other factor VIII products to moroctocog alfa albumin-free cell culture (AF-CC) in usual care settings. Thromb Haemost. 2015;114(4):676–684.
  4. Kelley B et al. An improved manufacturing process for Xyntha/ReFacto AF. Haemophilia 2010;16(5):717–725.
  5. ReFacto AF (moroctocog alfa) Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/6558/smpc
PP-REF-GBR-0196. March 2021

Contact Pfizer

Speak to a member of the Pfizer Haemophilia team.

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Find out about the ReFacto AF Laboratory Standard

How to order

Educational materials for children with haemophilia

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PP-PFE-GBR-2688. December 2020

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