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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Learn about the efficacy and safety of Somavert, its tumour impact and its effect on co-morbidity management through clinical and real world data

The acromegaly disease activity tool designed to help monitor your patients

Advice and support services to help you and your patients optimise your experience with Somavert about the efficacy and safety of Somavert through clinical and real world data

Learn about funding and reimbursement England, Scotland, Wales and Northern Ireland

Watch and listen to acromegaly experts talk about various topics in the disease area as well as recordings from our National Nurse Meeting and the Acromegaly co-morbidity series

Click here for Somavert® (pegvisomant) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Somavert is used in the treatment of adult patients with acromegaly who have had an inadequate response to surgery and/or radiation therapy and in whom an appropriate medical treatment with somatostatin analogues did not normalise IGF-I concentrations or was not tolerated.


Somavert has an established safety profile1-2

​​​​​​​Most common adverse events:

- Headaches (25%)1
- Arthralgia (16%)1
- Diarrhoea (13%)​​​​​​​1

Adverse events of interest:

Abnormal liver results (≥1/100 to <1/10)1 
- 3.2% of 2221 patients from ACROSTUDY had ALT/AST > 3 x ULN2
- Most elevations are transient with no reports of liver failure2

Injection site reactions (≥1/100 to <1/10)1
- 2% of 2221 patients from ACROSTUDY had treatment-related Injection site reactions2
- Most injection site reactions characterised as localised erythemas and soreness, spontaneously resolved with local symptomatic treatment, while pegvisomant therapy continued. Occurrence of injection site hypertrophy has been observed, including lipohypertrophy.1

Somavert safety profile

Over 2000 patients have participated in ACROSTUDY, the global safety surveillance study for Somavert to date, providing a wealth of information about possible adverse events1,2

For full details on side effects and selected adverse reactions please refer to the Somavert Summary of Product Characteristics1

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Monitoring of liver tests (LT)

Liver function should be assessed at baseline and monitored every 4-6 weeks for the first 6 months of treatment, or at any time in patients exhibiting symptoms suggestive of hepatitis. More frequent if elevations are detected at baseline. For full details regarding the assessment and monitoring of liver function please refer to the Summary of Product Characteristics.​​​​​​​1

Somavert efficacy

Discover IGF-I normalisation rates with Somavert

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Track IGF-I, symptoms and co-morbidities with ACRODAT

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To find out more about ACRODAT, supporting your patients or to order starter kits

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Starter kits

Help your patients feel confident with Somavert and self-administration 

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  1. Somavert Summary of Product Characteristics. Great Britain available here. Northern Ireland available here 
  2. Fleseriu M, et al. More then a decate of real-world experience of pegvisomant for acromegaly: ACROSTUDY. Eur J Endocrinol, 2021;185(4):525-38.
PP-SOM-GBR-1122. January 2022

For UK Healthcare Professionals*

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*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.

PP-PFE-GBR-3863. November 2021



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