Click here for Somavert® (pegvisomant) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.
Somavert is used in the treatment of adult patients with acromegaly who have had an inadequate response to surgery and/or radiation therapy and in whom an appropriate medical treatment with somatostatin analogues did not normalise IGF-I concentrations or was not tolerated.
- 2162 patients analysed for pituitary imaging
- 1795 patients had ≥1 pituitary imaging result
- 1276 (71.1%) patients had no change in pituitary tumour size, relative to their last examination based on local assessment
- 519 patients with a change in pituitary tumour size detected by local assessment: 128 (7.1%) with an increase only; 310 (17.3%) with a decrease only; and 81 (4.5%) with both an increase & decrease (observed at different timepoints).
- 264 out of the 1795 patients had MRI results assessed centrally which showed tumour volume increases in 54 (3.0%); decreases in 84 (4.7%); both increases & decreases in 12 (0.7%); no change in - 74 (4.1%) and insufficient data in 40 (2.2%)
- Changes in pituitary tumour size were reported as AEs of special interest in 96 (4.3%) of cases (24 (1.1%) considered treatment related) and caused 31 (1.4%) patients to discontinue pegvisomant treatment.1
To find out more about ACRODAT, supporting your patients or to order starter kits
** This is an optional area where footnotes can live.
References
1. M Fleseriu, et al. Eur J Endocrinol. 2021 Aug 27;185(4):525-538
2. Besser GM et al. Predictors and rates of treatment-resistant tumor growth in acromegaly. Eur J Endocrinol 2005;153:187–93.
3. Jiminez et al., Follow-up of pituitary tumour volume in patients with acromegaly treated with pegvisomant in clinical trials. European Journal of Endocrinology 2008: 159(5): 517–23.
These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
I confirm that I am a healthcare professional* resident in the United Kingdom.
If you select 'No', you will be redirected to Pfizer.co.uk where you will be able to access reference information on Pfizer's prescription medicines.
*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.
PP-PFE-GBR-3863. November 2021
No
OK, We will need you to sign in before we can determine if you are aligned with a Pfizer promotional colleague.This is an interstitial message to prompt a HCP before they login.
If you have already registered with pfizerpro.co.uk and select ‘yes’, you will be directed to the sign-in page where you will be required to enter your username and password.
Would you like to register or sign in now?