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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Learn about the efficacy and safety of Somavert, its tumour impact and its effect on co-morbidity management through clinical and real world data

The acromegaly disease activity tool designed to help monitor your patients

Advice and support services to help you and your patients optimise your experience with Somavert about the efficacy and safety of Somavert through clinical and real world data

Learn about funding and reimbursement England, Scotland, Wales and Northern Ireland

Watch and listen to acromegaly experts talk about various topics in the disease area as well as recordings from our National Nurse Meeting and the Acromegaly co-morbidity series

Click here for Somavert® (pegvisomant) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Somavert is used in the treatment of adult patients with acromegaly who have had an inadequate response to surgery and/or radiation therapy and in whom an appropriate medical treatment with somatostatin analogues did not normalise IGF-I concentrations or was not tolerated.

Tumour Impact

The majority of pituitary tumours remain stable with Somavert1

  • Although Somavert does not directly act on the pituitary tumour, 96.3% of patients experience maintained or decreased tumour size while on Somavert*1
  • Treatment-resistant tumour progression occurs in a small minority of patients with acromegaly, regardless of treatment modality2
  • When no tumour growth is observed in the first 18 months of treatment with Somavert, it is unlikely that any growth will occur subsequently3​​​​​​​

*As assessed by local ± central MRI analysis.​​​​​​​

Tumour stability during ACROSTUDY1,4

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Treatment impact on the tumour

Professor Richard Ross, Consultant Endocrinologist, University of Sheffield, discusses the various treatments for acromegaly and how they each impact the pituitary tumour

Track IGF-I, symptoms and co-morbidities with ACRODAT

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To find out more about ACRODAT, supporting your patients or to order starter kits 

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Treatment impact on diabetes 

Professor Partha Kar, Consultant in Diabetes and Endocrinology, Portsmouth Hospital NHS Trust, discusses the impact of acromegaly and its treatments on glycaemic control and diabetes

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References 

1. ACROSTUDY data on file. Final study report. November 2018.
2. Besser GM et al. Predictors and rates of treatment-resistant tumor growth in acromegaly. Eur J Endocrinol 2005;153:187–93.
3. Jiminez et al., Follow-up of pituitary tumour volume in patients with acromegaly treated with pegvisomant in clinical trials. European Journal of Endocrinology 2008: 159(5): 517–23.
4. Buchfelder M, et al. Long-term treatment with pegvisomant: observations from 2090 acromegaly patients in ACROSTUDY. Eur J Endocrinol, 2018;179(6):419–27.

PP-SOM-GBR-0952. June 2021

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PP-PFE-GBR-2688. December 2020

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