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Adverse event reporting can be found at the bottom of the page
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Prescribing Information for TOMUDEX® (raltitrexed) and adverse event reporting information can be found at the bottom of the page.
Raltitrexed is a cytotoxic agent and should be handled according to normal procedures adopted for such agents1.
The dose of raltitrexed is calculated on the basis of the body surface area. The recommended dose is 3 mg/m2 given intravenously, as a single short, intravenous infusion in 50 to 250 ml of either 0.9% sodium chloride solution or 5% dextrose (glucose) solution. It is recommended that the infusion is given over a 15 minute period1.
Other drugs should not be mixed with raltitrexed in the same infusion container. In the absence of toxicity, treatment may be repeated every 3 weeks1.
Dose escalation above 3 mg/m2 is not recommended, since higher doses have been associated with an increased incidence of life-threatening or fatal toxicity1.
Find out more about the tolerability profile of TOMUDEX
Explore more about how TOMUDEX can support your patients
Learn about TOMUDEX use in patients with fluoropyrimidine intolerance
Find out more about other Pfizer products
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References:
Prescribing Information
TOMUDEX:
TOMUDEX® (raltitrexed) 2 mg powder for solution for infusion – Prescribing Information Legal Category: POM. Basic NHS Price: 1 vial £148.75
OXALIPLATIN:
Oxaliplatin Vial 50mg/10ml Legal Category: POM. Basic NHS Price: 1 vial £156.75
Oxaliplatin Vial 100mg/20ml Legal Category: POM. Basic NHS Price: 1 vial £313.50
Oxaliplatin Vial 200mg/40ml Legal Category: POM. Basic NHS Price: 1 vial £627.00
Oxaliplatin 5mg/ml Concentrate for Solution for Infusion - Prescribing Information
FLUOROURACIL:
Fluorouracil Vial 500mg/20ml Legal Category: POM. Basic NHS Price: £64.00
Fluorouracil Vial 25mg/ml Legal Category: POM. Basic NHS Price: £32.00
Fluorouracil 25mg/ml Injection - Prescribing Information
Fluorouracil Vial 50mg/ml Legal Category: POM. Basic NHS Price: £64.00
Fluorouracil Vial 500mg/10ml Legal Category: POM. Basic NHS Price: £32.00
Fluorouracil Vial 2.5g/50ml Legal Category: POM. Basic NHS Price: £32.00
Fluorouracil 50mg/ml Injection - Prescribing Information
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search
for MHRA Yellow Card in Google Play or Apple App Store
Adverse events should also be reported to Pfizer Medical Information on 01304 616161
To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.
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These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
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PP-PFE-GBR-3863. November 2021