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Click here for Trumenba® (meningococcal group B vaccine (recombinant, adsorbed)) Prescribing Information for Great Britain (GB) and Northern Ireland (NI). Adverse event reporting information can be found at the bottom of the page.

Meningococcal group B vaccine

Trumenba (meningococcal group B vaccine (recombinant, adsorbed)) is indicated for active immunisation of individuals 10 years and older to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroup B.1

Vaccinate with Trumenba to help protect adolescents and young adults from MenB disease.1

Trumenba is a vaccine composed of 2 recombinant lipidated factor H binding protein (fHbp) variants.1 fHbp is found on the surface of meningococcal bacteria and helps bacteria to avoid host immune defences.
fHbp variants segregate into 2 immunologically distinct subfamilies, A and B.1 Over 91%** of MenB strains express sufficient levels of fHbp subfamily A or B to be susceptible to bactericidal killing by Trumenba induced antibodies.

​​​**A survey of over 2,150 different invasive meningococcal serogroup B isolates collected from 2000-2014 in 7 European countries, the US and Canada demonstrated that over 91% of all meningococcal serogroup B isolates expressed sufficient levels of fHbp to be susceptible to bactericidal killing by vaccine-induced antibodies.1.

Trumenba offers two dosing schedules for adolescents and young adults1


Dosing Schedules

2-dose schedule1
This includes 2 doses (0.5ml each) administered 6 months apart.

3-dose schedule1
This includes 2 doses (0.5ml each) administered at least 1 months apart, followed by a third dose at least 4 months after the second dose.


Dosing considerations1

  • A booster dose should be considered following either dosing regimen for individuals at continued risk of IMD.
  • The use of this vaccine should be in accordance with official recommendations1

Trumenba can be co-administered concomitantly with​​​​​​​:

  • Quadrivalent Human Papillomavirus vaccine (HPV4)
  • Meningococcal Serogroups A, C, W, Y conjugate vaccine (MenACWY)
  • Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed (Tdap)
  • Tetanus Toxoid, Reduced Diphtheria Toxoid, Acellular Pertussis, and Inactivated Poliovirus Vaccine (TdaP-IPV)
When given concomitantly with other vaccines Trumenba must be administered at a separate injection site.1 Trumenba should not be mixed with other vaccines in the same syringe.​​​​​​​

References​​
  1. Trumenba. Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/2670​​​​​​​
PP-TRU-GBR-0140. February 2022.

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PP-PFE-GBR-3863. November 2021

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